Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study

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This pilot study describes a single-arm trial using N-of-1 machine learning to personalize lifestyle interventions for individuals with mild-to-moderate depression. Participants utilized smartphone and smartwatch data to generate individualized mood augmentation plans, which were implemented over six weeks with health coach guidance. The resource reports on symptom reductions and cognitive improvements among completers, noting that automated algorithms could replicate the personalized targeting process.

ID
33b081c4bf9a43c8
Source org
PubMed Central
Author
Jason Nan (University of California San Diego), Suzanna Purpura (University of California San Diego), Satish Jaiswal (University of California San Diego), Houtan Afshar (University of California San Diego), Vojislav Marić (University of California San Diego), James Manchanda (University of California San Diego), Charles T. Taylor (University of California San Diego), Dhakshin Ramanathan (University of California San Diego), Jyoti Mishra (University of California San Diego)
Published
2026-05-19
OA status
diamond
DOI
10.1038/s44277-026-00062-3
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:33b081c4bf9a43c8,
  title = {Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study},
  author = {Jason Nan and Suzanna Purpura and Satish Jaiswal and Houtan Afshar and Vojislav Marić and James Manchanda and Charles T. Taylor and Dhakshin Ramanathan and Jyoti Mishra},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1038/s44277-026-00062-3},
  url = {https://doi.org/10.1038/s44277-026-00062-3}
}

RIS

TY  - JOUR
TI  - Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study
AU  - Nan, Jason
AU  - Purpura, Suzanna
AU  - Jaiswal, Satish
AU  - Afshar, Houtan
AU  - Marić, Vojislav
AU  - Manchanda, James
AU  - Taylor, Charles T.
AU  - Ramanathan, Dhakshin
AU  - Mishra, Jyoti
PY  - 2026
PB  - PubMed Central
DO  - 10.1038/s44277-026-00062-3
UR  - https://doi.org/10.1038/s44277-026-00062-3
ER  -

APA

Nan, J., Purpura, S., Jaiswal, S., Afshar, H., Marić, V., Manchanda, J., Taylor, C. T., Ramanathan, D., & Mishra, J. (2026). Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study. PubMed Central. https://doi.org/10.1038/s44277-026-00062-3

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