Effect of AI-Based Natural Language Feedback on Engagement and Clinical Outcomes in Fully Self-Guided Internet-Based Cognitive Behavioral Therapy for Depression: 3-Arm Randomized Controlled Trial

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This randomized controlled trial examines the impact of integrating natural language processing-based AI feedback into fully self-guided internet-based cognitive behavioral therapy for depression. The study compares an AI-augmented program against a standard iCBT version and a waitlist control among 1,187 adults, measuring depressive symptoms and engagement over seven weeks and three months. Results indicate that while AI support significantly improved weekly participation rates, particularly through empathic feedback, it did not yield significant between-group differences in mean symptom severity compared to the non-AI group in intention-to-treat analyses.

ID
d84420ef4bfb46f0
Source org
PubMed Central
Author
Mirai So (Tokyo Dental College), Yoichi Sekizawa (Research Institute of Economy, Trade and Industry), Sora Hashimoto (University of Tokyo Health Sciences), Masami Kashimura (Tokiwa University), Hajime Yamakage, Norio Watanabe
Published
2025-11-21
OA status
gold
DOI
10.2196/76902
PMID
Not recorded
PMCID
Not recorded
Citations
1

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BibTeX

@article{allodium:d84420ef4bfb46f0,
  title = {Effect of AI-Based Natural Language Feedback on Engagement and Clinical Outcomes in Fully Self-Guided Internet-Based Cognitive Behavioral Therapy for Depression: 3-Arm Randomized Controlled Trial},
  author = {Mirai So and Yoichi Sekizawa and Sora Hashimoto and Masami Kashimura and Hajime Yamakage and Norio Watanabe},
  year = {2025},
  journal = {PubMed Central},
  doi = {10.2196/76902},
  url = {https://doi.org/10.2196/76902}
}

RIS

TY  - JOUR
TI  - Effect of AI-Based Natural Language Feedback on Engagement and Clinical Outcomes in Fully Self-Guided Internet-Based Cognitive Behavioral Therapy for Depression: 3-Arm Randomized Controlled Trial
AU  - So, Mirai
AU  - Sekizawa, Yoichi
AU  - Hashimoto, Sora
AU  - Kashimura, Masami
AU  - Yamakage, Hajime
AU  - Watanabe, Norio
PY  - 2025
PB  - PubMed Central
DO  - 10.2196/76902
UR  - https://doi.org/10.2196/76902
ER  -

APA

So, M., Sekizawa, Y., Hashimoto, S., Kashimura, M., Yamakage, H., & Watanabe, N. (2025). Effect of AI-Based Natural Language Feedback on Engagement and Clinical Outcomes in Fully Self-Guided Internet-Based Cognitive Behavioral Therapy for Depression: 3-Arm Randomized Controlled Trial. PubMed Central. https://doi.org/10.2196/76902

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