A pilot randomized controlled trial of AI-delivered vs. human-delivered iCBT for depression in young adults

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This pilot randomized controlled trial compares the effectiveness and acceptability of AI-delivered versus human peer counselor-delivered internet-based Cognitive Behavioral Therapy for depressive symptoms in young adults. The study found that both interventions significantly reduced symptoms, with comparable results at week two, though the AI group experienced a plateau effect while the human group continued to improve. Qualitative feedback highlighted participant appreciation for AI convenience alongside concerns about its emotional understanding and personalization capabilities.

ID
3d82bb97448c4dfa
Source org
PubMed Central
Author
Yiyang Wu (Southern Medical University), Haoran Song (Southern Medical University), Chen Ye (Southern Medical University), Ruoyu Lin (Southern Medical University), Weihao Huang (Southern Medical University), You Wang (Zhujiang Hospital), Xia Yang (Zhujiang Hospital)
Published
2026-02-24
OA status
gold
DOI
10.1186/s12888-026-07925-1
PMID
Not recorded
PMCID
Not recorded
Citations
1

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BibTeX

@article{allodium:3d82bb97448c4dfa,
  title = {A pilot randomized controlled trial of AI-delivered vs. human-delivered iCBT for depression in young adults},
  author = {Yiyang Wu and Haoran Song and Chen Ye and Ruoyu Lin and Weihao Huang and You Wang and Xia Yang},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1186/s12888-026-07925-1},
  url = {https://doi.org/10.1186/s12888-026-07925-1}
}

RIS

TY  - JOUR
TI  - A pilot randomized controlled trial of AI-delivered vs. human-delivered iCBT for depression in young adults
AU  - Wu, Yiyang
AU  - Song, Haoran
AU  - Ye, Chen
AU  - Lin, Ruoyu
AU  - Huang, Weihao
AU  - Wang, You
AU  - Yang, Xia
PY  - 2026
PB  - PubMed Central
DO  - 10.1186/s12888-026-07925-1
UR  - https://doi.org/10.1186/s12888-026-07925-1
ER  - 

APA

Wu, Y., Song, H., Ye, C., Lin, R., Huang, W., Wang, Y., & Yang, X. (2026). A pilot randomized controlled trial of AI-delivered vs. human-delivered iCBT for depression in young adults. PubMed Central. https://doi.org/10.1186/s12888-026-07925-1

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