Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT)

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Overview

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This randomized controlled trial evaluates a generative AI-enabled CBT app against digital workbooks to assess user engagement and symptom reduction among adults with anxiety or depression. The study reports that the AI app significantly increased engagement frequency and duration compared to static materials, while showing comparable outcomes for anxiety and depression symptoms without increased adverse events. The resource is designed for readers interested in digital mental health interventions and the application of generative AI in therapeutic contexts.

ID
f342e302ec654405
Source org
PubMed Central
Author
Jessica McFadyen (Central Agency for Jewish Education), Johanna Habicht (Digital Catapult (United Kingdom)), Larisa-Maria Dina (King's College London), Ross Harper (Digital Catapult (United Kingdom)), Tobias U. Hauser (Prostate Cancer Research), Max Rollwage (Digital Catapult (United Kingdom))
Published
2026-01-15
OA status
gold
DOI
10.1038/s43856-025-01321-8
PMID
Not recorded
PMCID
Not recorded
Citations
5

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BibTeX

@article{allodium:f342e302ec654405,
  title = {Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT)},
  author = {Jessica McFadyen and Johanna Habicht and Larisa-Maria Dina and Ross Harper and Tobias U. Hauser and Max Rollwage},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1038/s43856-025-01321-8},
  url = {https://doi.org/10.1038/s43856-025-01321-8}
}

RIS

TY  - JOUR
TI  - Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT)
AU  - McFadyen, Jessica
AU  - Habicht, Johanna
AU  - Dina, Larisa-Maria
AU  - Harper, Ross
AU  - Hauser, Tobias U.
AU  - Rollwage, Max
PY  - 2026
PB  - PubMed Central
DO  - 10.1038/s43856-025-01321-8
UR  - https://doi.org/10.1038/s43856-025-01321-8
ER  -

APA

McFadyen, J., Habicht, J., Dina, L., Harper, R., Hauser, T. U., & Rollwage, M. (2026). Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT). PubMed Central. https://doi.org/10.1038/s43856-025-01321-8

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