Brain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths

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This research paper investigates whether structural and resting-state functional MRI data can predict treatment outcomes for pediatric anxiety following cognitive-behavioral therapy. Using connectome predictive modeling on two small datasets, the authors assessed the ability of brain connectivity features to forecast post-treatment symptom reduction. The study concludes that the models demonstrated low predictive accuracy and does not support the extensive use of this method for clinical prediction in this population.

ID
d0d27cfc6cf64a40
Source org
PubMed Central
Author
André Zugman (National Institutes of Health), Grace Ringlein (National Institutes of Health), Emily S. Finn (Dartmouth College), Krystal M. Lewis (National Institutes of Health), Erin Berman (National Institutes of Health), Wendy K. Silverman (Yale University), Eli R. Lebowitz (Yale University), Daniel S. Pine (National Institutes of Health), Anderson M. Winkler (National Institutes of Health)
Published
2025-01-01
OA status
hybrid
DOI
10.1017/S0033291724003131
PMID
Not recorded
PMCID
Not recorded
Citations
2

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BibTeX

@article{allodium:d0d27cfc6cf64a40,
  title = {Brain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths},
  author = {André Zugman and Grace Ringlein and Emily S. Finn and Krystal M. Lewis and Erin Berman and Wendy K. Silverman and Eli R. Lebowitz and Daniel S. Pine and Anderson M. Winkler},
  year = {2025},
  journal = {PubMed Central},
  doi = {10.1017/S0033291724003131},
  url = {https://doi.org/10.1017/S0033291724003131}
}

RIS

TY  - JOUR
TI  - Brain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths
AU  - Zugman, André
AU  - Ringlein, Grace
AU  - Finn, Emily S.
AU  - Lewis, Krystal M.
AU  - Berman, Erin
AU  - Silverman, Wendy K.
AU  - Lebowitz, Eli R.
AU  - Pine, Daniel S.
AU  - Winkler, Anderson M.
PY  - 2025
PB  - PubMed Central
DO  - 10.1017/S0033291724003131
UR  - https://doi.org/10.1017/S0033291724003131
ER  -

APA

Zugman, A., Ringlein, G., Finn, E. S., Lewis, K. M., Berman, E., Silverman, W. K., Lebowitz, E. R., Pine, D. S., & Winkler, A. M. (2025). Brain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths. PubMed Central. https://doi.org/10.1017/S0033291724003131

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