Fields · Health Sciences · Medicine · Physiology

Alzheimer's disease research and treatments

This cluster of papers focuses on the research and mechanisms related to Alzheimer's disease, including the amyloid hypothesis, tau pathology, protein misfolding, neuroinflammation, synaptic dysfunction, oxidative stress, genetic associations, Aß oligomers, neurodegeneration, and therapeutic strategies.

120,143 works

Papers listed on taxonomy pages are the top few works per node from the OpenAlex snapshot. That list is not exhaustive and is not an endorsement. The topic map and the journal registry remain separate: there is still no authoritative topic-to-venue or topic-to-organization edge. Search is a lexical lookup, not a claim that a venue publishes a topic.

Most cited

  1. Neuropathological stageing of Alzheimer-related changes

    Heiko Braak, Eva Braak · 1991 · Acta Neuropathologica · 16,518 citations

  2. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

    John Hardy, Dennis J. Selkoe · 2002 · Science · 13,955 citations

  3. Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

    Maj-Linda B. Selenica, Milene L. Brownlow, Jeffy P. Jimenez, Daniel C. Lee · 2012 · Neurodegenerative Diseases · 10,402 citations

  4. Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

    Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter, D. E. Schmechel · 1993 · Science · 9,540 citations

  5. Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

    Reisa A. Sperling, Paul Aisen, Laurel Beckett, David A. Bennett · 2011 · Alzheimer s & Dementia · 7,248 citations

  6. Protein Misfolding, Functional Amyloid, and Human Disease

    Fabrizio Chiti, Christopher M. Dobson · 2006 · Annual Review of Biochemistry · 6,461 citations

Most recent

  1. The emerging role of proteomics in Alzheimer’s disease: Moving beyond single biomarkers

    Ivona Jankuloska, Marija Hiljadnikova‐Bajro · 2026 · DOAJ (DOAJ: Directory of Open Access Journals) · 0 citations

  2. Alzheimer's beta secretases: pathology, pharmacology and evolution at the dawn of the nervous system

    Southan Christopher · 2026 · Zenodo (CERN European Organization for Nuclear Research) · 0 citations

  3. The Need for a Fast-track Pathway to Streamline Disease-modifying Treatments in Early Alzheimer’s Disease

    Durjoy Lahiri · 2026 · Canadian Geriatrics Journal · 0 citations

  4. Covalent linkage of the papillomavirus E2 DNA-binding domain reveals a soluble amyloid-like assembly pathway

    Mariano Dellarole, Ignacio E. Sánchez, Cecilia Bebeacua, Silvio Juan Ludueña · 2026 · Scientific Reports · 0 citations

  5. Impaired amyloid-beta uptake and distinct transcriptomic profiles of monocytes in APOE4 carriers: The Chongqing Ageing and Dementia Study

    Zhi-Hao Liu, Jiang-Hui Li, Jin-Nan Jiang, Heng Yang · 2026 · Translational Psychiatry · 0 citations

  6. Modeling Tau-Mediated Pathology in Monkey Brain Slices

    Mingtian Pan, Qintian Guo, Peisi Huang, Xiang Han · 2026 · Biology · 0 citations

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