Fields · Health Sciences · Medicine · Physiology

Pain Mechanisms and Treatments

This cluster of papers explores the mechanisms, diagnosis, and treatment of neuropathic pain, focusing on central sensitization, neuroinflammation, glial activation, and the modulation of pain perception. It covers topics such as nociception, neuronal plasticity, chronic pain, hyperalgesia, and diabetic neuropathy.

106,806 works

Papers listed on taxonomy pages are the top few works per node from the OpenAlex snapshot. That list is not exhaustive and is not an endorsement. The topic map and the journal registry remain separate: there is still no authoritative topic-to-venue or topic-to-organization edge. Search is a lexical lookup, not a claim that a venue publishes a topic.

Most cited

  1. Pain Mechanisms: A New Theory

    Ronald Melzack, Patrick D. Wall · 1965 · Science · 11,086 citations

  2. Quantitative assessment of tactile allodynia in the rat paw

    Sandra R. Chaplan, Flemming W. Bach, J W Pogrel, Jin Mo Chung · 1994 · Journal of Neuroscience Methods · 7,938 citations

  3. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

    Gary J. Bennett, Yuanyu Xie · 1988 · Pain · 5,385 citations

  4. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

    Kenneth Hargreaves, Ronald Dubner, Frederick J. Brown, Carmen‐Lisset Flores · 1988 · Pain · 5,212 citations

  5. Central sensitization: Implications for the diagnosis and treatment of pain

    Clifford J. Woolf · 2010 · Pain · 4,682 citations

  6. Cellular and Molecular Mechanisms of Pain

    Allan I. Basbaum, Diana M. Bautista, Grégory Scherrer, David Julius · 2009 · Cell · 4,339 citations

Most recent

  1. Elevated translocator protein in skull bone marrow is linked to human chronic pain

    Mehrbod Mohammadian, Nikos Efthimiou, Katherin A. Gabriel, Ludovica Brusaferri · 2026 · Science Translational Medicine · 1 citations

  2. Rapid peripheral reprogramming of myelinated afferents contributes to human hyperalgesia

    Saad S. Nagi, Otmane Bouchatta, S. Lindström, Ahmed Barakat · 2026 · Zenodo (CERN European Organization for Nuclear Research) · 0 citations

  3. Neuroimmune crosstalk in osteoarthritis pain: from synovial inflammation to pain sensitization

    毛中彦, Kang Wang, Yanxuan Wu, Gongchang Yu · 2026 · Frontiers in Immunology · 0 citations

  4. Psychometric validation of the Turkish version of the Neuropathic Pain Symptom Inventory

    Serpil Savaş, Ayşegül Garip Honamlıoğlu, Adnan Karaibrahimoğlu, Serpil Demirci · 2026 · Turkish Journal of Physical Medicine and Rehabilitation · 0 citations

  5. Single-cell and single-nucleus transcriptomics of the dorsal root ganglion in neuropathic pain: cell-state remodeling and translational prospects

    Xu-Ran liao, Huan Zheng, Jiang-Yuan Luo, Bixin Zheng · 2026 · Journal of Translational Medicine · 0 citations

  6. Emerging Pharmacological Approaches in Peripheral Neuropathy: Current Perspectives and Future Directions

    Kallepalli Anil Varma* · 2026 · 0 citations

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