Cardiovascular disease and depression: a bidirectional relationship and its clinical implications

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This review examines the bidirectional relationship between depression and cardiovascular disease, detailing shared pathophysiological mechanisms such as neuroendocrine dysregulation and inflammatory activation. It discusses how each condition can predispose individuals to the other and outlines current multimodal treatment strategies that combine pharmacotherapy, cognitive behavioral therapy, and lifestyle modifications. The resource is intended for clinicians and researchers interested in the clinical implications of this comorbidity.

ID
1713615a5e6748b9
Source org
PubMed Central
Author
Jianbo Wu (Nanchang University), Zifan Tian (Nanchang University), Zhimin Qi (Nanchang University), Xia Liu (Jiujiang University), Peng Yu (Nanchang University)
Published
2026-01-12
OA status
gold
DOI
10.3389/fpsyt.2025.1675680
PMID
Not recorded
PMCID
Not recorded
Citations
5

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BibTeX

@article{allodium:1713615a5e6748b9,
  title = {Cardiovascular disease and depression: a bidirectional relationship and its clinical implications},
  author = {Jianbo Wu and Zifan Tian and Zhimin Qi and Xia Liu and Peng Yu},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.3389/fpsyt.2025.1675680},
  url = {https://doi.org/10.3389/fpsyt.2025.1675680}
}

RIS

TY  - JOUR
TI  - Cardiovascular disease and depression: a bidirectional relationship and its clinical implications
AU  - Wu, Jianbo
AU  - Tian, Zifan
AU  - Qi, Zhimin
AU  - Liu, Xia
AU  - Yu, Peng
PY  - 2026
PB  - PubMed Central
DO  - 10.3389/fpsyt.2025.1675680
UR  - https://doi.org/10.3389/fpsyt.2025.1675680
ER  -

APA

Wu, J., Tian, Z., Qi, Z., Liu, X., & Yu, P. (2026). Cardiovascular disease and depression: a bidirectional relationship and its clinical implications. PubMed Central. https://doi.org/10.3389/fpsyt.2025.1675680

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