Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression

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This fMRI study compares neural activity in nondepressed individuals and those with major depressive disorder during emotion regulation tasks. It reports that depressed participants exhibit bilateral prefrontal cortex activation and a positive association between the ventromedial prefrontal cortex and amygdala, contrasting with the left-lateralized activation and inverse connectivity seen in healthy controls. The resource suggests that counterproductive recruitment of specific prefrontal-subcortical circuits may underlie the pathophysiology of depression.

ID
1d10a00ae0884350
Source org
OpenAlex
Author
Tom Johnstone (University of Wisconsin–Madison), Carien M. van Reekum (University of Wisconsin–Madison), Heather L. Urry (Tufts University), Ned H. Kalin (University of Wisconsin–Madison), Richard J. Davidson (University of Wisconsin–Madison)
Published
2007-08-15
OA status
bronze
DOI
10.1523/jneurosci.2063-07.2007
PMID
Not recorded
PMCID
Not recorded
Citations
1059

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BibTeX

@article{allodium:1d10a00ae0884350,
  title = {Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression},
  author = {Tom Johnstone and Carien M. van Reekum and Heather L. Urry and Ned H. Kalin and Richard J. Davidson},
  year = {2007},
  journal = {OpenAlex},
  doi = {10.1523/jneurosci.2063-07.2007},
  url = {https://doi.org/10.1523/jneurosci.2063-07.2007}
}

RIS

TY  - JOUR
TI  - Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression
AU  - Johnstone, Tom
AU  - Reekum, Carien M. van
AU  - Urry, Heather L.
AU  - Kalin, Ned H.
AU  - Davidson, Richard J.
PY  - 2007
PB  - OpenAlex
DO  - 10.1523/jneurosci.2063-07.2007
UR  - https://doi.org/10.1523/jneurosci.2063-07.2007
ER  -

APA

Johnstone, T., Reekum, C. M. V., Urry, H. L., Kalin, N. H., & Davidson, R. J. (2007). Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression. OpenAlex. https://doi.org/10.1523/jneurosci.2063-07.2007

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