Psilocybin in the Treatment of Cocaine Use Disorder

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Overview

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This randomized clinical trial investigates the efficacy of a single psilocybin dose combined with manualized psychotherapy for cocaine use disorder compared to an active placebo. The study included 40 adults and measured outcomes such as abstinence rates and time to first lapse over 180 days post-treatment. Results indicated that participants receiving psilocybin showed higher percentages of abstinent days and greater likelihood of complete abstinence than the control group.

ID
4d76058a5eaf4438
Source org
PubMed Central
Author
Peter S. Hendricks (University of Alabama at Birmingham), Sara Lappan (University of Alabama at Birmingham), Richard C. Shelton (University of Alabama at Birmingham), Adrienne C. Lahti (University of Alabama at Birmingham), Karen L. Cropsey (University of Alabama at Birmingham), Matthew W. Johnson (Johns Hopkins University), Melissa Bradley (University of Alabama at Birmingham), Otto Simonsson (Karolinska Institutet), Lori L. Davis (Birmingham VA Medical Center), Daniel H. Grossman (University of Alabama at Birmingham), Cynthia E. Ortiz (University of Alabama at Birmingham)
Published
2026-05-07
OA status
gold
DOI
10.1001/jamanetworkopen.2026.11029
PMID
Not recorded
PMCID
Not recorded
Citations
4

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BibTeX

@article{allodium:4d76058a5eaf4438,
  title = {Psilocybin in the Treatment of Cocaine Use Disorder},
  author = {Peter S. Hendricks and Sara Lappan and Richard C. Shelton and Adrienne C. Lahti and Karen L. Cropsey and Matthew W. Johnson and Melissa Bradley and Otto Simonsson and Lori L. Davis and Daniel H. Grossman and Cynthia E. Ortiz},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1001/jamanetworkopen.2026.11029},
  url = {https://doi.org/10.1001/jamanetworkopen.2026.11029}
}

RIS

TY  - JOUR
TI  - Psilocybin in the Treatment of Cocaine Use Disorder
AU  - Hendricks, Peter S.
AU  - Lappan, Sara
AU  - Shelton, Richard C.
AU  - Lahti, Adrienne C.
AU  - Cropsey, Karen L.
AU  - Johnson, Matthew W.
AU  - Bradley, Melissa
AU  - Simonsson, Otto
AU  - Davis, Lori L.
AU  - Grossman, Daniel H.
AU  - Ortiz, Cynthia E.
PY  - 2026
PB  - PubMed Central
DO  - 10.1001/jamanetworkopen.2026.11029
UR  - https://doi.org/10.1001/jamanetworkopen.2026.11029
ER  -

APA

Hendricks, P. S., Lappan, S., Shelton, R. C., Lahti, A. C., Cropsey, K. L., Johnson, M. W., Bradley, M., Simonsson, O., Davis, L. L., Grossman, D. H., & Ortiz, C. E. (2026). Psilocybin in the Treatment of Cocaine Use Disorder. PubMed Central. https://doi.org/10.1001/jamanetworkopen.2026.11029

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