Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression

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This randomized clinical trial compares the efficacy of Mindfulness-Based Cognitive Therapy, maintenance antidepressant pharmacotherapy, and placebo for preventing depressive relapse in patients who have achieved remission from recurrent major depressive disorder. The study involved 84 participants who were followed for 18 months to assess relapse rates based on their assigned intervention group. Results indicated that both MBCT and maintenance medication significantly reduced the hazard of relapse compared to placebo among patients with unstable remission, while no significant differences were observed among those with stable remission.

ID
9b91a967e028439a
Source org
OpenAlex
Author
Zindel V. Segal (Centre for Addiction and Mental Health), Peter Bieling (Centre for Addiction and Mental Health), Trevor M. Young, Glenda MacQueen (Centre for Addiction and Mental Health), R.G. Cooke (Centre for Addiction and Mental Health), Lawrence Martin (Centre for Addiction and Mental Health), Richard T. Bloch (Centre for Addiction and Mental Health), Robert D. Levitan (Centre for Addiction and Mental Health)
Published
2010-12-06
OA status
bronze
DOI
10.1001/archgenpsychiatry.2010.168
PMID
Not recorded
PMCID
Not recorded
Citations
435

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BibTeX

@article{allodium:9b91a967e028439a,
  title = {Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression},
  author = {Zindel V. Segal and Peter Bieling and Trevor M. Young and Glenda MacQueen and R.G. Cooke and Lawrence Martin and Richard T. Bloch and Robert D. Levitan},
  year = {2010},
  journal = {OpenAlex},
  doi = {10.1001/archgenpsychiatry.2010.168},
  url = {https://doi.org/10.1001/archgenpsychiatry.2010.168}
}

RIS

TY  - JOUR
TI  - Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression
AU  - Segal, Zindel V.
AU  - Bieling, Peter
AU  - Young, Trevor M.
AU  - MacQueen, Glenda
AU  - Cooke, R.G.
AU  - Martin, Lawrence
AU  - Bloch, Richard T.
AU  - Levitan, Robert D.
PY  - 2010
PB  - OpenAlex
DO  - 10.1001/archgenpsychiatry.2010.168
UR  - https://doi.org/10.1001/archgenpsychiatry.2010.168
ER  -

APA

Segal, Z. V., Bieling, P., Young, T. M., MacQueen, G., Cooke, R., Martin, L., Bloch, R. T., & Levitan, R. D. (2010). Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression. OpenAlex. https://doi.org/10.1001/archgenpsychiatry.2010.168

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