The Potential Relationship Between Low Back Pain and Depression: A Comprehensive Review

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This review examines the bidirectional relationship between low back pain and depression, highlighting shared biological mechanisms such as HPA axis dysregulation and neuroinflammation. It discusses how psychological factors like stress and anxiety contribute to this comorbidity and notes that both conditions affect similar brain regions involved in pain and emotional regulation. The resource suggests that effective management requires interdisciplinary approaches addressing both physical and psychological aspects, suitable for clinicians or researchers interested in the neurobiological links between these conditions.

ID
50f1443d8fd64f61
Source org
PubMed Central
Author
力伟 曹 (Jiangxi University of Traditional Chinese Medicine), Biao Deng (Jiangxi University of Traditional Chinese Medicine), Xiaole Wang (Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine), Ting Fang (Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine), KuyikAbasi Nsima Umoh (Jiangxi University of Traditional Chinese Medicine), Lang Liu (Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine), Jiaming Qian (Jiangxi University of Traditional Chinese Medicine), Fushui Liu (Jiangxi University of Traditional Chinese Medicine)
Published
2025-11-01
OA status
gold
DOI
10.1002/brb3.71026
PMID
Not recorded
PMCID
Not recorded
Citations
7

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Cite this entry

BibTeX

@article{allodium:50f1443d8fd64f61,
  title = {The Potential Relationship Between Low Back Pain and Depression: A Comprehensive Review},
  author = {力伟 曹 and Biao Deng and Xiaole Wang and Ting Fang and KuyikAbasi Nsima Umoh and Lang Liu and Jiaming Qian and Fushui Liu},
  year = {2025},
  journal = {PubMed Central},
  doi = {10.1002/brb3.71026},
  url = {https://doi.org/10.1002/brb3.71026}
}

RIS

TY  - JOUR
TI  - The Potential Relationship Between Low Back Pain and Depression: A Comprehensive Review
AU  - 曹, 力伟
AU  - Deng, Biao
AU  - Wang, Xiaole
AU  - Fang, Ting
AU  - Umoh, KuyikAbasi Nsima
AU  - Liu, Lang
AU  - Qian, Jiaming
AU  - Liu, Fushui
PY  - 2025
PB  - PubMed Central
DO  - 10.1002/brb3.71026
UR  - https://doi.org/10.1002/brb3.71026
ER  -

APA

曹, 力., Deng, B., Wang, X., Fang, T., Umoh, K. N., Liu, L., Qian, J., & Liu, F. (2025). The Potential Relationship Between Low Back Pain and Depression: A Comprehensive Review. PubMed Central. https://doi.org/10.1002/brb3.71026

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