Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder

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This paper reports on a phase 2 clinical trial investigating the safety and efficacy of adjunctive ketamine infusions combined with mindfulness-based relapse prevention therapy for patients with severe alcohol use disorder. The study compared ketamine plus therapy against placebo plus therapy, as well as ketamine plus education versus saline plus education, across 96 participants. Results indicated that ketamine treatment was well tolerated and associated with a greater number of abstinent days at six-month follow-up, though no significant difference in relapse rates was observed between the ketamine and placebo groups.

ID
58a67cf0555b402a
Source org
OpenAlex
Author
Meryem Grabski (PerkinElmer (United States)), Amy McAndrew (PerkinElmer (United States)), Will Lawn (PerkinElmer (United States)), Beth Marsh (PerkinElmer (United States)), Laura Raymen (PerkinElmer (United States)), Tobias Stevens (PerkinElmer (United States)), Lorna Hardy (PerkinElmer (United States)), Fiona C Warren (PerkinElmer (United States)), Michael Bloomfield (University of Exeter), Anna Borissova (PerkinElmer (United States)), Emily L. Maschauer (PerkinElmer (United States)), Rupert Broomby (Royal Devon & Exeter NHS Foundation Trust), Robert L. Price (PerkinElmer (United States)), Rachel Coathup (Royal Devon & Exeter NHS Foundation Trust), David Gilhooly (PerkinElmer (United States)), Edward Palmer (PerkinElmer (United States)), Richard Gordon-Williams (PerkinElmer (United States)), Robert D. Hill (PerkinElmer (United States)), J. A. Harris (South London and Maudsley NHS Foundation Trust), Özden Merve Mollaahmetoğlu (South London and Maudsley NHS Foundation Trust), H. Valerie Curran (PerkinElmer (United States)), Brigitta Brandner (PerkinElmer (United States)), Anne Lingford‐Hughes (PerkinElmer (United States)), Celia J. A. Morgan (PerkinElmer (United States))
Published
2022-01-11
OA status
green
DOI
10.1176/appi.ajp.2021.21030277
PMID
Not recorded
PMCID
Not recorded
Citations
169

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BibTeX

@article{allodium:58a67cf0555b402a,
  title = {Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder},
  author = {Meryem Grabski and Amy McAndrew and Will Lawn and Beth Marsh and Laura Raymen and Tobias Stevens and Lorna Hardy and Fiona C Warren and Michael Bloomfield and Anna Borissova and Emily L. Maschauer and Rupert Broomby and Robert L. Price and Rachel Coathup and David Gilhooly and Edward Palmer and Richard Gordon-Williams and Robert D. Hill and J. A. Harris and Özden Merve Mollaahmetoğlu and H. Valerie Curran and Brigitta Brandner and Anne Lingford‐Hughes and Celia J. A. Morgan},
  year = {2022},
  journal = {OpenAlex},
  doi = {10.1176/appi.ajp.2021.21030277},
  url = {https://doi.org/10.1176/appi.ajp.2021.21030277}
}

RIS

TY  - JOUR
TI  - Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder
AU  - Grabski, Meryem
AU  - McAndrew, Amy
AU  - Lawn, Will
AU  - Marsh, Beth
AU  - Raymen, Laura
AU  - Stevens, Tobias
AU  - Hardy, Lorna
AU  - Warren, Fiona C
AU  - Bloomfield, Michael
AU  - Borissova, Anna
AU  - Maschauer, Emily L.
AU  - Broomby, Rupert
AU  - Price, Robert L.
AU  - Coathup, Rachel
AU  - Gilhooly, David
AU  - Palmer, Edward
AU  - Gordon-Williams, Richard
AU  - Hill, Robert D.
AU  - Harris, J. A.
AU  - Mollaahmetoğlu, Özden Merve
AU  - Curran, H. Valerie
AU  - Brandner, Brigitta
AU  - Lingford‐Hughes, Anne
AU  - Morgan, Celia J. A.
PY  - 2022
PB  - OpenAlex
DO  - 10.1176/appi.ajp.2021.21030277
UR  - https://doi.org/10.1176/appi.ajp.2021.21030277
ER  -

APA

Grabski, M., McAndrew, A., Lawn, W., Marsh, B., Raymen, L., Stevens, T., Hardy, L., Warren, F. C., Bloomfield, M., Borissova, A., Maschauer, E. L., Broomby, R., Price, R. L., Coathup, R., Gilhooly, D., Palmer, E., Gordon-Williams, R., Hill, R. D., Harris, J. A., Mollaahmetoğlu, Ö. M., Curran, H. V., Brandner, B., Lingford‐Hughes, A., & Morgan, C. J. A. (2022). Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder. OpenAlex. https://doi.org/10.1176/appi.ajp.2021.21030277

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