The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial

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This study uses sequential mediation analysis to examine how an adapted Collaborative Care Model influences glycemic control in Indian adults with type 2 diabetes and depressive symptoms. The research identifies a pathway where reduced depression leads to improved positive health behaviors, which subsequently lower BMI and waist circumference, ultimately improving HbA1c levels. It is primarily relevant for researchers and clinicians interested in the mechanisms underlying integrated cardiometabolic and mental health interventions.

ID
58e945a553ca418a
Source org
PubMed Central
Author
Zachary Cooper (University of Georgia), Leslie Johnson (Emory University), Shivani A. Patel (Emory University), Aravind Sosale (Diacon Hospital), Nikhil Tandon (All India Institute of Medical Sciences), Ranjit Mohan Anjana (Madras Diabetes Research Foundation), Subramani Poongothai (Madras Diabetes Research Foundation), GR Sridhar, Viswanathan Mohan (Madras Diabetes Research Foundation), Lydia Chwastiak (University of Washington), Mohammed K. Ali (Emory University)
Published
2025-08-13
OA status
hybrid
DOI
10.1007/s11606-025-09810-1
PMID
Not recorded
PMCID
Not recorded
Citations
4

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BibTeX

@article{allodium:58e945a553ca418a,
  title = {The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial},
  author = {Zachary Cooper and Leslie Johnson and Shivani A. Patel and Aravind Sosale and Nikhil Tandon and Ranjit Mohan Anjana and Subramani Poongothai and GR Sridhar and Viswanathan Mohan and Lydia Chwastiak and Mohammed K. Ali},
  year = {2025},
  journal = {PubMed Central},
  doi = {10.1007/s11606-025-09810-1},
  url = {https://doi.org/10.1007/s11606-025-09810-1}
}

RIS

TY  - JOUR
TI  - The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial
AU  - Cooper, Zachary
AU  - Johnson, Leslie
AU  - Patel, Shivani A.
AU  - Sosale, Aravind
AU  - Tandon, Nikhil
AU  - Anjana, Ranjit Mohan
AU  - Poongothai, Subramani
AU  - Sridhar, GR
AU  - Mohan, Viswanathan
AU  - Chwastiak, Lydia
AU  - Ali, Mohammed K.
PY  - 2025
PB  - PubMed Central
DO  - 10.1007/s11606-025-09810-1
UR  - https://doi.org/10.1007/s11606-025-09810-1
ER  -

APA

Cooper, Z., Johnson, L., Patel, S. A., Sosale, A., Tandon, N., Anjana, R. M., Poongothai, S., Sridhar, G., Mohan, V., Chwastiak, L., & Ali, M. K. (2025). The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial. PubMed Central. https://doi.org/10.1007/s11606-025-09810-1

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