Modifiers in Effects of Combined Pharmacotherapy and Psychotherapy versus Pharmacotherapy Alone for Adult Depression: An Individual Participant Data Meta-Analysis

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This individual participant data meta-analysis evaluates whether specific patient or study characteristics modify the comparative effectiveness of combined pharmacotherapy and psychotherapy versus pharmacotherapy alone for adult depression. The authors analyzed data from 31 randomized trials involving 3,703 participants to identify effect modifiers for outcomes such as symptom reduction and remission. The resource reports that combined treatment was generally more effective than medication alone across various follow-up periods, with no specific patient-level characteristics identified as significant effect modifiers.

ID
7958334fb25344b7
Source org
PubMed Central
Author
Markéta Čihařová (Vrije Universiteit Amsterdam), Eirini Karyotaki (United Nations Institute for Training and Research), Mathias Harrer (United Nations Institute for Training and Research), Erica Weitz (University of Pennsylvania), Clara Miguel (Vrije Universiteit Amsterdam), Arpana Amarnath (Vrije Universiteit Amsterdam), Toshi A. Furukawa (Kyoto University), Constantin Yves Plessen (Medical University of Graz), Ellen Driessen (Radboud University Nijmegen), Claudia Buntrock (Otto-von-Guericke-Universität Magdeburg), Lingyao Tong (Vrije Universiteit Amsterdam), David J. Hellerstein (New York Psychoanalytic Society and Institute), Lisa Wallner Samstag (Long Island University), Ying Chen (New York Psychoanalytic Society and Institute), R Sreevani (Institute of Mental Health), Curt Hemanny (Instituto de Saúde), Irismar Reis de Oliveira (Universidade Federal da Bahia), Blom Mb (Parnassia Groep), Y. Burnand (University Hospital of Geneva), Antonio Andreoli (University Hospital of Geneva), Andrea K. Wittenborn (Michigan State University), Kevin L. Delucchi (University of California, San Francisco), Nusrat Husain (University of Manchester), Robert J. DeRubeis (University of Pennsylvania), Joel M. Town (Dalhousie University)
Published
2026-01-21
OA status
hybrid
DOI
10.1159/000550633
PMID
Not recorded
PMCID
Not recorded
Citations
1

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BibTeX

@article{allodium:7958334fb25344b7,
  title = {Modifiers in Effects of Combined Pharmacotherapy and Psychotherapy versus Pharmacotherapy Alone for Adult Depression: An Individual Participant Data Meta-Analysis},
  author = {Markéta Čihařová and Eirini Karyotaki and Mathias Harrer and Erica Weitz and Clara Miguel and Arpana Amarnath and Toshi A. Furukawa and Constantin Yves Plessen and Ellen Driessen and Claudia Buntrock and Lingyao Tong and David J. Hellerstein and Lisa Wallner Samstag and Ying Chen and R Sreevani and Curt Hemanny and Irismar Reis de Oliveira and Blom Mb and Y. Burnand and Antonio Andreoli and Andrea K. Wittenborn and Kevin L. Delucchi and Nusrat Husain and Robert J. DeRubeis and Joel M. Town},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1159/000550633},
  url = {https://doi.org/10.1159/000550633}
}

RIS

TY  - JOUR
TI  - Modifiers in Effects of Combined Pharmacotherapy and Psychotherapy versus Pharmacotherapy Alone for Adult Depression: An Individual Participant Data Meta-Analysis
AU  - Čihařová, Markéta
AU  - Karyotaki, Eirini
AU  - Harrer, Mathias
AU  - Weitz, Erica
AU  - Miguel, Clara
AU  - Amarnath, Arpana
AU  - Furukawa, Toshi A.
AU  - Plessen, Constantin Yves
AU  - Driessen, Ellen
AU  - Buntrock, Claudia
AU  - Tong, Lingyao
AU  - Hellerstein, David J.
AU  - Samstag, Lisa Wallner
AU  - Chen, Ying
AU  - Sreevani, R
AU  - Hemanny, Curt
AU  - Oliveira, Irismar Reis de
AU  - Mb, Blom
AU  - Burnand, Y.
AU  - Andreoli, Antonio
AU  - Wittenborn, Andrea K.
AU  - Delucchi, Kevin L.
AU  - Husain, Nusrat
AU  - DeRubeis, Robert J.
AU  - Town, Joel M.
PY  - 2026
PB  - PubMed Central
DO  - 10.1159/000550633
UR  - https://doi.org/10.1159/000550633
ER  -

APA

Čihařová, M., Karyotaki, E., Harrer, M., Weitz, E., Miguel, C., Amarnath, A., Furukawa, T. A., Plessen, C. Y., Driessen, E., Buntrock, C., Tong, L., Hellerstein, D. J., Samstag, L. W., Chen, Y., Sreevani, R., Hemanny, C., Oliveira, I. R. D., Mb, B., Burnand, Y., Andreoli, A., Wittenborn, A. K., Delucchi, K. L., Husain, N., DeRubeis, R. J., & Town, J. M. (2026). Modifiers in Effects of Combined Pharmacotherapy and Psychotherapy versus Pharmacotherapy Alone for Adult Depression: An Individual Participant Data Meta-Analysis. PubMed Central. https://doi.org/10.1159/000550633

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