D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders

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This meta-analysis investigates whether D-cycloserine augments exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders. The study analyzes individual participant data from 21 randomized clinical trials to assess efficacy and potential interactions with antidepressants. Results indicate that D-cycloserine led to greater improvement compared to placebo at posttreatment, but not at midtreatment or follow-up stages.

ID
8912e84255e149ae
Source org
OpenAlex
Author
David Mataix‐Cols (Stockholm County Council), Lorena Fernández de la Cruz (Karolinska Institutet), Benedetta Monzani (King's College London), David Rosenfield (Southern Methodist University), Erik Andersson (Karolinska Institutet), Ana Pérez-Vigil (Karolinska Institutet), Paolo Frumento (Karolinska Institutet), Rianne A. de Kleine (Radboud University Nijmegen), JoAnn Difede (Cornell University), Boadie W. Dunlop (Emory University), Lara J. Farrell (Griffith University), Daniel Geller (Harvard University), Maryrose Gerardi (Emory University), Adam J. Guastella (The University of Sydney), Stefan G. Hofmann (Boston University), Gert‐Jan Hendriks (Radboud University Nijmegen), Matt G. Kushner (University of Minnesota), Francis S. Lee (Cornell University), Eric J. Lenze (Washington University in St. Louis), Cheri A. Levinson (University of Louisville), Harry McConnell (Griffith University), Michael W. Otto (Boston University), Jens Plag (Charité - Universitätsmedizin Berlin), Mark H. Pollack (Rush University Medical Center), Kerry J. Ressler (Harvard University)
Published
2017-01-25
OA status
green
DOI
10.1001/jamapsychiatry.2016.3955
PMID
Not recorded
PMCID
Not recorded
Citations
294

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BibTeX

@article{allodium:8912e84255e149ae,
  title = {D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders},
  author = {David Mataix‐Cols and Lorena Fernández de la Cruz and Benedetta Monzani and David Rosenfield and Erik Andersson and Ana Pérez-Vigil and Paolo Frumento and Rianne A. de Kleine and JoAnn Difede and Boadie W. Dunlop and Lara J. Farrell and Daniel Geller and Maryrose Gerardi and Adam J. Guastella and Stefan G. Hofmann and Gert‐Jan Hendriks and Matt G. Kushner and Francis S. Lee and Eric J. Lenze and Cheri A. Levinson and Harry McConnell and Michael W. Otto and Jens Plag and Mark H. Pollack and Kerry J. Ressler},
  year = {2017},
  journal = {OpenAlex},
  doi = {10.1001/jamapsychiatry.2016.3955},
  url = {https://doi.org/10.1001/jamapsychiatry.2016.3955}
}

RIS

TY  - JOUR
TI  - D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders
AU  - Mataix‐Cols, David
AU  - Cruz, Lorena Fernández de la
AU  - Monzani, Benedetta
AU  - Rosenfield, David
AU  - Andersson, Erik
AU  - Pérez-Vigil, Ana
AU  - Frumento, Paolo
AU  - Kleine, Rianne A. de
AU  - Difede, JoAnn
AU  - Dunlop, Boadie W.
AU  - Farrell, Lara J.
AU  - Geller, Daniel
AU  - Gerardi, Maryrose
AU  - Guastella, Adam J.
AU  - Hofmann, Stefan G.
AU  - Hendriks, Gert‐Jan
AU  - Kushner, Matt G.
AU  - Lee, Francis S.
AU  - Lenze, Eric J.
AU  - Levinson, Cheri A.
AU  - McConnell, Harry
AU  - Otto, Michael W.
AU  - Plag, Jens
AU  - Pollack, Mark H.
AU  - Ressler, Kerry J.
PY  - 2017
PB  - OpenAlex
DO  - 10.1001/jamapsychiatry.2016.3955
UR  - https://doi.org/10.1001/jamapsychiatry.2016.3955
ER  -

APA

Mataix‐Cols, D., Cruz, L. F. D. L., Monzani, B., Rosenfield, D., Andersson, E., Pérez-Vigil, A., Frumento, P., Kleine, R. A. D., Difede, J., Dunlop, B. W., Farrell, L. J., Geller, D., Gerardi, M., Guastella, A. J., Hofmann, S. G., Hendriks, G., Kushner, M. G., Lee, F. S., Lenze, E. J., Levinson, C. A., McConnell, H., Otto, M. W., Plag, J., Pollack, M. H., & Ressler, K. J. (2017). D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders. OpenAlex. https://doi.org/10.1001/jamapsychiatry.2016.3955

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