Trauma re-experiencing episodes during esketamine treatment in patients with treatment-resistant depression and comorbid PTSD: a retrospective case series

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This retrospective case series examines trauma re-experiencing episodes in 22 adult patients with treatment-resistant depression and comorbid PTSD during esketamine nasal spray treatment. The study reports that while some patients discontinued treatment due to these episodes, others continued with favorable clinical outcomes for both conditions. The resource is intended for clinicians or researchers interested in the safety and efficacy of esketamine for this specific comorbidity.

ID
938030a1d19f4cf0
Source org
PubMed Central
Author
Maud Rothärmel (Centre Hospitalier du Rouvray), L. Mekaoui (FHU Neurovasc), François Kazour (Centre Hospitalier Universitaire d'Angers), Morgane Herrero (Centre Hospitalier Universitaire de Saint-Étienne), Eva-Maria Beetz-Lobono, Aistė Lengvenytė (Centre National de la Recherche Scientifique), Jérôme Holtzmann (Centre Hospitalier Universitaire de Grenoble), P Raynaud (University of Fukui Hospital), Macarena Cuenca (Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale), Samuel Bulteau (methodS in Patient-centered outcomes and HEalth ResEarch), Pierre de Maricourt (Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale), Thomas Husson (Centre Hospitalier du Rouvray), Emilie Olié (Centre National de la Recherche Scientifique), B. Gohier (Centre Hospitalier Universitaire d'Angers), A. Sauvaget (methodS in Patient-centered outcomes and HEalth ResEarch), Raphaël Gaillard (Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale), Raphaëlle Richieri (Aix-Marseille Université), David Szekely, Ludovic Samalin (University of Clermont Auvergne), Olivier Guillin (Centre Hospitalier du Rouvray), Virginie Moulier (Hôpital de Ville-Évrard), Wissam El-Hage (Inserm), Andrew Laurin (methodS in Patient-centered outcomes and HEalth ResEarch), Lucie Berkovitch (Université Paris Cité)
Published
2026-04-01
OA status
gold
DOI
10.1080/20008066.2025.2609425
PMID
Not recorded
PMCID
Not recorded
Citations
1

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BibTeX

@article{allodium:938030a1d19f4cf0,
  title = {Trauma re-experiencing episodes during esketamine treatment in patients with treatment-resistant depression and comorbid PTSD: a retrospective case series},
  author = {Maud Rothärmel and L. Mekaoui and François Kazour and Morgane Herrero and Eva-Maria Beetz-Lobono and Aistė Lengvenytė and Jérôme Holtzmann and P Raynaud and Macarena Cuenca and Samuel Bulteau and Pierre de Maricourt and Thomas Husson and Emilie Olié and B. Gohier and A. Sauvaget and Raphaël Gaillard and Raphaëlle Richieri and David Szekely and Ludovic Samalin and Olivier Guillin and Virginie Moulier and Wissam El-Hage and Andrew Laurin and Lucie Berkovitch},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1080/20008066.2025.2609425},
  url = {https://doi.org/10.1080/20008066.2025.2609425}
}

RIS

TY  - JOUR
TI  - Trauma re-experiencing episodes during esketamine treatment in patients with treatment-resistant depression and comorbid PTSD: a retrospective case series
AU  - Rothärmel, Maud
AU  - Mekaoui, L.
AU  - Kazour, François
AU  - Herrero, Morgane
AU  - Beetz-Lobono, Eva-Maria
AU  - Lengvenytė, Aistė
AU  - Holtzmann, Jérôme
AU  - Raynaud, P
AU  - Cuenca, Macarena
AU  - Bulteau, Samuel
AU  - Maricourt, Pierre de
AU  - Husson, Thomas
AU  - Olié, Emilie
AU  - Gohier, B.
AU  - Sauvaget, A.
AU  - Gaillard, Raphaël
AU  - Richieri, Raphaëlle
AU  - Szekely, David
AU  - Samalin, Ludovic
AU  - Guillin, Olivier
AU  - Moulier, Virginie
AU  - El-Hage, Wissam
AU  - Laurin, Andrew
AU  - Berkovitch, Lucie
PY  - 2026
PB  - PubMed Central
DO  - 10.1080/20008066.2025.2609425
UR  - https://doi.org/10.1080/20008066.2025.2609425
ER  -

APA

Rothärmel, M., Mekaoui, L., Kazour, F., Herrero, M., Beetz-Lobono, E., Lengvenytė, A., Holtzmann, J., Raynaud, P., Cuenca, M., Bulteau, S., Maricourt, P. D., Husson, T., Olié, E., Gohier, B., Sauvaget, A., Gaillard, R., Richieri, R., Szekely, D., Samalin, L., Guillin, O., Moulier, V., El-Hage, W., Laurin, A., & Berkovitch, L. (2026). Trauma re-experiencing episodes during esketamine treatment in patients with treatment-resistant depression and comorbid PTSD: a retrospective case series. PubMed Central. https://doi.org/10.1080/20008066.2025.2609425

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