Ketamine and Esketamine in Obsessive–Compulsive Disorder: A Scoping Review of Clinical and Mechanistic Evidence

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This scoping review maps preclinical and clinical evidence regarding the use of ketamine and esketamine for obsessive-compulsive disorder, focusing on glutamatergic mechanisms. It synthesizes findings from twenty-one studies to assess the potential of these NMDA receptor antagonists as rapid-acting interventions for treatment-refractory cases. The resource is intended for researchers and clinicians interested in emerging pharmacological treatments for OCD.

ID
ff6719180ebf4fab
Source org
PubMed Central
Author
Maria Marmureanu (Spitalul Clinic de Psihiatrie Alexandru Obregia), Mariana Valy Besoiu (Carol Davila University of Medicine and Pharmacy), Vlad Dionisie (Carol Davila University of Medicine and Pharmacy), Mihnea Costin Manea (Carol Davila University of Medicine and Pharmacy), Mihnea Costin Manea (Carol Davila University of Medicine and Pharmacy), Cătălin Pleșea-Condratovici ("Dunarea de Jos" University of Galati), Sorana Iulia Voican (Spitalul Clinic de Psihiatrie Alexandru Obregia), Mirela Manea (Carol Davila University of Medicine and Pharmacy), Mirela Manea (Carol Davila University of Medicine and Pharmacy)
Published
2026-04-16
OA status
gold
DOI
10.3390/ph19040628
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:ff6719180ebf4fab,
  title = {Ketamine and Esketamine in Obsessive–Compulsive Disorder: A Scoping Review of Clinical and Mechanistic Evidence},
  author = {Maria Marmureanu and Mariana Valy Besoiu and Vlad Dionisie and Mihnea Costin Manea and Mihnea Costin Manea and Cătălin Pleșea-Condratovici and Sorana Iulia Voican and Mirela Manea and Mirela Manea},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.3390/ph19040628},
  url = {https://doi.org/10.3390/ph19040628}
}

RIS

TY  - JOUR
TI  - Ketamine and Esketamine in Obsessive–Compulsive Disorder: A Scoping Review of Clinical and Mechanistic Evidence
AU  - Marmureanu, Maria
AU  - Besoiu, Mariana Valy
AU  - Dionisie, Vlad
AU  - Manea, Mihnea Costin
AU  - Manea, Mihnea Costin
AU  - Pleșea-Condratovici, Cătălin
AU  - Voican, Sorana Iulia
AU  - Manea, Mirela
AU  - Manea, Mirela
PY  - 2026
PB  - PubMed Central
DO  - 10.3390/ph19040628
UR  - https://doi.org/10.3390/ph19040628
ER  -

APA

Marmureanu, M., Besoiu, M. V., Dionisie, V., Manea, M. C., Manea, M. C., Pleșea-Condratovici, C., Voican, S. I., Manea, M., & Manea, M. (2026). Ketamine and Esketamine in Obsessive–Compulsive Disorder: A Scoping Review of Clinical and Mechanistic Evidence. PubMed Central. https://doi.org/10.3390/ph19040628

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