Towards Mechanism‐Informed Treatments for Mental Health

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This review discusses the limitations of current neuropsychiatric treatments that primarily target dopamine and serotonin, advocating for a broader focus on other neuromodulatory systems such as acetylcholine, norepinephrine, and endocannabinoids. It examines the role of these additional pathways in conditions like depression, schizophrenia, and anxiety, while also highlighting the importance of sex-specific neurobiological differences. The resource is intended for researchers and clinicians interested in mechanism-based therapeutic strategies and recent clinical trial progress.

ID
52a9490ce39d4d45
Source org
PubMed Central
Author
Iker Bengoetxea de Tena (University of the Basque Country), Farhanah Nabilah Sallie (University of the Witwatersrand), Arvie Rodriguez Abiero (Charles Darwin University), Beatrice Rizzi (University of Milan), Leandro Gabriel Champarini (Universidad Nacional de Córdoba), Elisa Corti (University of Coimbra), Gianluca Masella (University of Coimbra), Ariel L. Dunn (Monash University), Luisa Bandeira Binder (Université Laval), Tyler J. Wenzel (University of Saskatchewan), Agustin I. Robles (Pontificia Universidad Católica de Chile), Roberta G. Anversa (Florey Institute of Neuroscience and Mental Health), Cécilia Tremblay (Douglas College), Aliance Romain Fokoua (Université de Dschang), Randriely Merscher Sobreira de Lima (McGill University), Mateus D'Ávila (Yale University), Trang T. T. Truong (Deakin University), Jessica C. Pierce (Maxwell Institute for Mathematical Sciences), Rui S. Rodrigues (Université de Bordeaux), Luis Dinamarca‐Villarroel (Pontificia Universidad Católica de Chile), Felipe Borges Almeida (Universidade Federal de Ciências da Saúde de Porto Alegre), Aino‐Kaisa Piironen (University of Eastern Finland), Andrey F. L. Aguiar (Universidade Federal do Rio de Janeiro), Andrés M. Jaramillo (Leibniz Institute for Neurobiology), Lucas Santos (Universidade Federal do Rio Grande do Sul)
Published
2026-05-01
OA status
green
DOI
10.1111/jnc.70477
PMID
Not recorded
PMCID
Not recorded
Citations
1

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BibTeX

@article{allodium:52a9490ce39d4d45,
  title = {Towards Mechanism‐Informed Treatments for Mental Health},
  author = {Iker Bengoetxea de Tena and Farhanah Nabilah Sallie and Arvie Rodriguez Abiero and Beatrice Rizzi and Leandro Gabriel Champarini and Elisa Corti and Gianluca Masella and Ariel L. Dunn and Luisa Bandeira Binder and Tyler J. Wenzel and Agustin I. Robles and Roberta G. Anversa and Cécilia Tremblay and Aliance Romain Fokoua and Randriely Merscher Sobreira de Lima and Mateus D'Ávila and Trang T. T. Truong and Jessica C. Pierce and Rui S. Rodrigues and Luis Dinamarca‐Villarroel and Felipe Borges Almeida and Aino‐Kaisa Piironen and Andrey F. L. Aguiar and Andrés M. Jaramillo and Lucas Santos},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1111/jnc.70477},
  url = {https://doi.org/10.1111/jnc.70477}
}

RIS

TY  - JOUR
TI  - Towards Mechanism‐Informed Treatments for Mental Health
AU  - Tena, Iker Bengoetxea de
AU  - Sallie, Farhanah Nabilah
AU  - Abiero, Arvie Rodriguez
AU  - Rizzi, Beatrice
AU  - Champarini, Leandro Gabriel
AU  - Corti, Elisa
AU  - Masella, Gianluca
AU  - Dunn, Ariel L.
AU  - Binder, Luisa Bandeira
AU  - Wenzel, Tyler J.
AU  - Robles, Agustin I.
AU  - Anversa, Roberta G.
AU  - Tremblay, Cécilia
AU  - Fokoua, Aliance Romain
AU  - Lima, Randriely Merscher Sobreira de
AU  - D'Ávila, Mateus
AU  - Truong, Trang T. T.
AU  - Pierce, Jessica C.
AU  - Rodrigues, Rui S.
AU  - Dinamarca‐Villarroel, Luis
AU  - Almeida, Felipe Borges
AU  - Piironen, Aino‐Kaisa
AU  - Aguiar, Andrey F. L.
AU  - Jaramillo, Andrés M.
AU  - Santos, Lucas
PY  - 2026
PB  - PubMed Central
DO  - 10.1111/jnc.70477
UR  - https://doi.org/10.1111/jnc.70477
ER  -

APA

Tena, I. B. D., Sallie, F. N., Abiero, A. R., Rizzi, B., Champarini, L. G., Corti, E., Masella, G., Dunn, A. L., Binder, L. B., Wenzel, T. J., Robles, A. I., Anversa, R. G., Tremblay, C., Fokoua, A. R., Lima, R. M. S. D., D'Ávila, M., Truong, T. T. T., Pierce, J. C., Rodrigues, R. S., Dinamarca‐Villarroel, L., Almeida, F. B., Piironen, A., Aguiar, A. F. L., Jaramillo, A. M., & Santos, L. (2026). Towards Mechanism‐Informed Treatments for Mental Health. PubMed Central. https://doi.org/10.1111/jnc.70477

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