Switching to Another SSRI or to Venlafaxine With or Without Cognitive Behavioral Therapy for Adolescents With SSRI-Resistant Depression

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This randomized controlled trial evaluates four treatment strategies for 334 adolescents aged 12 to 18 who did not respond to an initial SSRI for major depressive disorder. The study compares switching to a second SSRI or venlafaxine, with or without the addition of cognitive behavioral therapy. It reports response rates and adverse event profiles across these groups.

ID
ce65a70a1293450b
Source org
OpenAlex
Author
David A. Brent (University of Pittsburgh), Graham J. Emslie, Gregory N. Clarke (Kaiser Permanente), Karen Dineen Wagner (The University of Texas Medical Branch at Galveston), Joan Rosenbaum Asarnow (University of California, Los Angeles), Marty Keller (John Brown University), Benedetto Vitiello (National Institutes of Health), Louise Ritz (National Institutes of Health), Satish Iyengar (University of Pittsburgh), Kaleab Z. Abebe (University of Pittsburgh), Boris Birmaher (University of Pittsburgh), Neal D. Ryan (University of Pittsburgh), Betsy D. Kennard, Carroll W. Hughes, Lynn DeBar (Kaiser Permanente), James T. McCracken (University of California, Los Angeles), Michael Strober (University of California, Los Angeles), Robert Suddath (University of California, Los Angeles), Anthony Spirito (John Brown University), Henrietta Leonard (John Brown University), Nadine Melhem (University of Pittsburgh), Giovanna Porta (University of Pittsburgh), Matthew Onorato (Nationwide Children's Hospital), Jamie Zelazny (University of Pittsburgh)
Published
2008-02-26
OA status
bronze
DOI
10.1001/jama.299.8.901
PMID
Not recorded
PMCID
Not recorded
Citations
703

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BibTeX

@article{allodium:ce65a70a1293450b,
  title = {Switching to Another SSRI or to Venlafaxine With or Without Cognitive Behavioral Therapy for Adolescents With SSRI-Resistant Depression},
  author = {David A. Brent and Graham J. Emslie and Gregory N. Clarke and Karen Dineen Wagner and Joan Rosenbaum Asarnow and Marty Keller and Benedetto Vitiello and Louise Ritz and Satish Iyengar and Kaleab Z. Abebe and Boris Birmaher and Neal D. Ryan and Betsy D. Kennard and Carroll W. Hughes and Lynn DeBar and James T. McCracken and Michael Strober and Robert Suddath and Anthony Spirito and Henrietta Leonard and Nadine Melhem and Giovanna Porta and Matthew Onorato and Jamie Zelazny},
  year = {2008},
  journal = {OpenAlex},
  doi = {10.1001/jama.299.8.901},
  url = {https://doi.org/10.1001/jama.299.8.901}
}

RIS

TY  - JOUR
TI  - Switching to Another SSRI or to Venlafaxine With or Without Cognitive Behavioral Therapy for Adolescents With SSRI-Resistant Depression
AU  - Brent, David A.
AU  - Emslie, Graham J.
AU  - Clarke, Gregory N.
AU  - Wagner, Karen Dineen
AU  - Asarnow, Joan Rosenbaum
AU  - Keller, Marty
AU  - Vitiello, Benedetto
AU  - Ritz, Louise
AU  - Iyengar, Satish
AU  - Abebe, Kaleab Z.
AU  - Birmaher, Boris
AU  - Ryan, Neal D.
AU  - Kennard, Betsy D.
AU  - Hughes, Carroll W.
AU  - DeBar, Lynn
AU  - McCracken, James T.
AU  - Strober, Michael
AU  - Suddath, Robert
AU  - Spirito, Anthony
AU  - Leonard, Henrietta
AU  - Melhem, Nadine
AU  - Porta, Giovanna
AU  - Onorato, Matthew
AU  - Zelazny, Jamie
PY  - 2008
PB  - OpenAlex
DO  - 10.1001/jama.299.8.901
UR  - https://doi.org/10.1001/jama.299.8.901
ER  -

APA

Brent, D. A., Emslie, G. J., Clarke, G. N., Wagner, K. D., Asarnow, J. R., Keller, M., Vitiello, B., Ritz, L., Iyengar, S., Abebe, K. Z., Birmaher, B., Ryan, N. D., Kennard, B. D., Hughes, C. W., DeBar, L., McCracken, J. T., Strober, M., Suddath, R., Spirito, A., Leonard, H., Melhem, N., Porta, G., Onorato, M., & Zelazny, J. (2008). Switching to Another SSRI or to Venlafaxine With or Without Cognitive Behavioral Therapy for Adolescents With SSRI-Resistant Depression. OpenAlex. https://doi.org/10.1001/jama.299.8.901

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