Dorsolateral Prefrontal Cortex Activity Predicts Responsiveness to Cognitive–Behavioral Therapy in Schizophrenia

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This study investigates whether pre-treatment brain activity in the dorsolateral prefrontal cortex (DLPFC) predicts clinical improvement in patients with schizophrenia receiving cognitive-behavioral therapy (CBT). The research involved fifty-two outpatients and twenty healthy controls undergoing functional magnetic resonance imaging during a working memory task, followed by a comparison of outcomes between those who received CBT plus treatment-as-usual versus those who received only standard care. Results indicate that stronger DLPFC activity and its connectivity with the cerebellum are associated with greater responsiveness to CBT.

ID
eee9b47aadcb4cac
Source org
OpenAlex
Author
Veena Kumari (National Health Service), Emmanuelle Peters (National Health Service), Dominic Fannon (King's College London), Elena Antonova (King's College London), Preethi Premkumar (King's College London), Anantha P. Anilkumar (King's College London), Steven Williams (Wellcome Centre for Human Neuroimaging), Elizabeth Kuipers (National Health Service)
Published
2009-06-28
OA status
hybrid
DOI
10.1016/j.biopsych.2009.04.036
PMID
Not recorded
PMCID
Not recorded
Citations
119

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BibTeX

@article{allodium:eee9b47aadcb4cac,
  title = {Dorsolateral Prefrontal Cortex Activity Predicts Responsiveness to Cognitive–Behavioral Therapy in Schizophrenia},
  author = {Veena Kumari and Emmanuelle Peters and Dominic Fannon and Elena Antonova and Preethi Premkumar and Anantha P. Anilkumar and Steven Williams and Elizabeth Kuipers},
  year = {2009},
  journal = {OpenAlex},
  doi = {10.1016/j.biopsych.2009.04.036},
  url = {https://doi.org/10.1016/j.biopsych.2009.04.036}
}

RIS

TY  - JOUR
TI  - Dorsolateral Prefrontal Cortex Activity Predicts Responsiveness to Cognitive–Behavioral Therapy in Schizophrenia
AU  - Kumari, Veena
AU  - Peters, Emmanuelle
AU  - Fannon, Dominic
AU  - Antonova, Elena
AU  - Premkumar, Preethi
AU  - Anilkumar, Anantha P.
AU  - Williams, Steven
AU  - Kuipers, Elizabeth
PY  - 2009
PB  - OpenAlex
DO  - 10.1016/j.biopsych.2009.04.036
UR  - https://doi.org/10.1016/j.biopsych.2009.04.036
ER  -

APA

Kumari, V., Peters, E., Fannon, D., Antonova, E., Premkumar, P., Anilkumar, A. P., Williams, S., & Kuipers, E. (2009). Dorsolateral Prefrontal Cortex Activity Predicts Responsiveness to Cognitive–Behavioral Therapy in Schizophrenia. OpenAlex. https://doi.org/10.1016/j.biopsych.2009.04.036

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