Efficacy, moderators and mediators of cognitive behavioural analysis system of psychotherapy (CBASP) versus behavioural activation (BA) in persistently depressed treatment-resistant inpatients: study protocol for the multicentre, randomised controlled changePDD trial

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This study protocol outlines a multicentre randomised controlled trial comparing Cognitive Behavioural Analysis System of Psychotherapy (CBASP) with Behavioural Activation (BA) for adults with treatment-resistant persistent depressive disorder in an inpatient setting. The research aims to assess short- and long-term efficacy, safety, and health-economic benefits while exploring moderators and mediators of treatment effects. It is designed for clinicians and researchers interested in evidence-based guidance for selecting psychotherapies for this specific patient population.

ID
030db5548743451c
Source org
PubMed Central
Author
Eva-Lotta Brakemeier (Universität Greifswald), Jan Philipp Klein (University of Lübeck), Johannes Zimmermann (University of Kassel), Maike Hollandt (Universität Greifswald), Matthias A. Reinhard (LMU Klinikum), Sabrina Boger (LMU Klinikum), Luisa Daldrup (Charité - Universitätsmedizin Berlin), Luk Eldem (University Hospital Bonn), Philippa Gebhardt (Medizinische Hochschule Hannover), S.M. Heinrich (Charité - Universitätsmedizin Berlin), Matthias Hirsmueller (STZ eyetrial), Jacob Millerowski (University Hospital Bonn), Martina Richter (Jena University Hospital), Isabelle C. Ridderbusch (Philipps University of Marburg), Svenja Suerig (University of Lübeck), Lennart Schroeter (Medizinische Hochschule Hannover), Kerstin Velten-Schurian (STZ eyetrial), Stefan Engeli (Universitätsmedizin Greifswald), Amelie Witte (Universitätsmedizin Greifswald), Malek Bajbouj (German Centre for Cardiovascular Research), Andreas J. Fallgatter (German Center for Infection Research), Kai G Kahl (Medizinische Hochschule Hannover), Tilo Kircher (Philipps University of Marburg), Stephan Köhler (Charité - Universitätsmedizin Berlin), A. Philipsen (University Hospital Bonn)
Published
2026-04-01
OA status
gold
DOI
10.1136/bmjopen-2025-107051
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:030db5548743451c,
  title = {Efficacy, moderators and mediators of cognitive behavioural analysis system of psychotherapy (CBASP) versus behavioural activation (BA) in persistently depressed treatment-resistant inpatients: study protocol for the multicentre, randomised controlled changePDD trial},
  author = {Eva-Lotta Brakemeier and Jan Philipp Klein and Johannes Zimmermann and Maike Hollandt and Matthias A. Reinhard and Sabrina Boger and Luisa Daldrup and Luk Eldem and Philippa Gebhardt and S.M. Heinrich and Matthias Hirsmueller and Jacob Millerowski and Martina Richter and Isabelle C. Ridderbusch and Svenja Suerig and Lennart Schroeter and Kerstin Velten-Schurian and Stefan Engeli and Amelie Witte and Malek Bajbouj and Andreas J. Fallgatter and Kai G Kahl and Tilo Kircher and Stephan Köhler and A. Philipsen},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1136/bmjopen-2025-107051},
  url = {https://doi.org/10.1136/bmjopen-2025-107051}
}

RIS

TY  - JOUR
TI  - Efficacy, moderators and mediators of cognitive behavioural analysis system of psychotherapy (CBASP) versus behavioural activation (BA) in persistently depressed treatment-resistant inpatients: study protocol for the multicentre, randomised controlled changePDD trial
AU  - Brakemeier, Eva-Lotta
AU  - Klein, Jan Philipp
AU  - Zimmermann, Johannes
AU  - Hollandt, Maike
AU  - Reinhard, Matthias A.
AU  - Boger, Sabrina
AU  - Daldrup, Luisa
AU  - Eldem, Luk
AU  - Gebhardt, Philippa
AU  - Heinrich, S.M.
AU  - Hirsmueller, Matthias
AU  - Millerowski, Jacob
AU  - Richter, Martina
AU  - Ridderbusch, Isabelle C.
AU  - Suerig, Svenja
AU  - Schroeter, Lennart
AU  - Velten-Schurian, Kerstin
AU  - Engeli, Stefan
AU  - Witte, Amelie
AU  - Bajbouj, Malek
AU  - Fallgatter, Andreas J.
AU  - Kahl, Kai G
AU  - Kircher, Tilo
AU  - Köhler, Stephan
AU  - Philipsen, A.
PY  - 2026
PB  - PubMed Central
DO  - 10.1136/bmjopen-2025-107051
UR  - https://doi.org/10.1136/bmjopen-2025-107051
ER  -

APA

Brakemeier, E., Klein, J. P., Zimmermann, J., Hollandt, M., Reinhard, M. A., Boger, S., Daldrup, L., Eldem, L., Gebhardt, P., Heinrich, S., Hirsmueller, M., Millerowski, J., Richter, M., Ridderbusch, I. C., Suerig, S., Schroeter, L., Velten-Schurian, K., Engeli, S., Witte, A., Bajbouj, M., Fallgatter, A. J., Kahl, K. G., Kircher, T., Köhler, S., & Philipsen, A. (2026). Efficacy, moderators and mediators of cognitive behavioural analysis system of psychotherapy (CBASP) versus behavioural activation (BA) in persistently depressed treatment-resistant inpatients: study protocol for the multicentre, randomised controlled changePDD trial. PubMed Central. https://doi.org/10.1136/bmjopen-2025-107051

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