Negative effects of mindfulness-based cognitive therapy and cognitive behavioural analysis system of psychotherapy for patients with ‘difficult to treat’ depression: protocol for a systematic review and individual participant data meta-analysis

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This protocol outlines a systematic review and individual participant data meta-analysis comparing the negative effects of mindfulness-based cognitive therapy (MBCT) and cognitive behavioural analysis system of psychotherapy (CBASP) for adults with difficult-to-treat depression. The study aims to assess clinically significant deterioration, suicidality, and treatment dropout rates by analyzing data from randomized controlled trials. It is designed to inform clinical decision-making and guideline development regarding potential adverse outcomes in this vulnerable population.

ID
b3b682077b264e33
Source org
PubMed Central
Author
Maria Niemi (Karolinska Institutet), Johannes Michalak (Witten/Herdecke University), Maria Velana (Witten/Herdecke University), Thorsten Barnhofer (University of Surrey), Mathias Harrer (Vrije Universiteit Amsterdam)
Published
2026-04-01
OA status
gold
DOI
10.1136/bmjopen-2025-106362
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:b3b682077b264e33,
  title = {Negative effects of mindfulness-based cognitive therapy and cognitive behavioural analysis system of psychotherapy for patients with ‘difficult to treat’ depression: protocol for a systematic review and individual participant data meta-analysis},
  author = {Maria Niemi and Johannes Michalak and Maria Velana and Thorsten Barnhofer and Mathias Harrer},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1136/bmjopen-2025-106362},
  url = {https://doi.org/10.1136/bmjopen-2025-106362}
}

RIS

TY  - JOUR
TI  - Negative effects of mindfulness-based cognitive therapy and cognitive behavioural analysis system of psychotherapy for patients with ‘difficult to treat’ depression: protocol for a systematic review and individual participant data meta-analysis
AU  - Niemi, Maria
AU  - Michalak, Johannes
AU  - Velana, Maria
AU  - Barnhofer, Thorsten
AU  - Harrer, Mathias
PY  - 2026
PB  - PubMed Central
DO  - 10.1136/bmjopen-2025-106362
UR  - https://doi.org/10.1136/bmjopen-2025-106362
ER  -

APA

Niemi, M., Michalak, J., Velana, M., Barnhofer, T., & Harrer, M. (2026). Negative effects of mindfulness-based cognitive therapy and cognitive behavioural analysis system of psychotherapy for patients with ‘difficult to treat’ depression: protocol for a systematic review and individual participant data meta-analysis. PubMed Central. https://doi.org/10.1136/bmjopen-2025-106362

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