Study protocol of a randomized controlled superiority trial of Huddinge Online Prolonged Exposure therapy (HOPE) for adults with posttraumatic stress disorder

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This study protocol outlines a randomized controlled superiority trial evaluating the effectiveness of HOPE, a digital therapist-guided prolonged exposure program for adults with PTSD. The research compares ten weeks of this intervention against an active control condition involving psychoeducation and relaxation, targeting 286 participants in a clinical setting. It measures primary outcomes such as PTSD symptom severity using clinician-administered scales, alongside secondary metrics like depression, quality of life, and cost-effectiveness.

ID
31b3b702128b4d17
Source org
PubMed Central
Author
Maria Bragesjö (Karolinska Institutet), Volen Z. Ivanov (Karolinska Institutet), Erik Andersson (Karolinska Institutet), Christian Rück (Karolinska Institutet)
Published
2025-12-12
OA status
gold
DOI
10.1186/s13063-025-09361-0
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:31b3b702128b4d17,
  title = {Study protocol of a randomized controlled superiority trial of Huddinge Online Prolonged Exposure therapy (HOPE) for adults with posttraumatic stress disorder},
  author = {Maria Bragesjö and Volen Z. Ivanov and Erik Andersson and Christian Rück},
  year = {2025},
  journal = {PubMed Central},
  doi = {10.1186/s13063-025-09361-0},
  url = {https://doi.org/10.1186/s13063-025-09361-0}
}

RIS

TY  - JOUR
TI  - Study protocol of a randomized controlled superiority trial of Huddinge Online Prolonged Exposure therapy (HOPE) for adults with posttraumatic stress disorder
AU  - Bragesjö, Maria
AU  - Ivanov, Volen Z.
AU  - Andersson, Erik
AU  - Rück, Christian
PY  - 2025
PB  - PubMed Central
DO  - 10.1186/s13063-025-09361-0
UR  - https://doi.org/10.1186/s13063-025-09361-0
ER  -

APA

Bragesjö, M., Ivanov, V. Z., Andersson, E., & Rück, C. (2025). Study protocol of a randomized controlled superiority trial of Huddinge Online Prolonged Exposure therapy (HOPE) for adults with posttraumatic stress disorder. PubMed Central. https://doi.org/10.1186/s13063-025-09361-0

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