Safety and preliminary efficacy of Aurora: a pilot, non-randomized clinical trial of a culturally adapted digital cognitive behavioral therapy intervention for anxiety and depression in Mexico

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This pilot study evaluates Aurora, a culturally adapted Spanish-language digital CBT program for anxiety and depression in Mexico, as an adjunct to pharmacotherapy. The non-randomized trial involved 34 adults with generalized anxiety disorder, comparing the intervention group against a control group receiving medication alone over 12 weeks. Results indicated that while both groups saw reductions in anxiety symptoms, the Aurora group experienced significantly greater decreases in pathological worry and showed a favorable safety profile with no serious adverse events.

ID
64b9bf6448a04a40
Source org
PubMed Central
Author
Edith Zárate (Istituto Psicoanalitico per le Ricerche Sociali), Augusto César Velasco-Téllez (Fundación Chile), Lucia Araceli Sanchez-Reyes (Fundación Chile), Angel Mario Coll-Muñoz (Hospital de Especialidades), Miguel Á. Ramírez-Ramírez (Hospital de Especialidades), Alejandro López Tello (Ibero American University), Christian Gabriel Toledo-Lozano (Institute for Social Security and Services for State Workers), Ana Moreno-Coutiño (Universidad Nacional de La Plata), María del Pilar Callejas-Gómez, Raúl Durón-Figueroa (Universidad Nacional Autónoma de México), Lorena Alejandra Flores-Plata (Universidad Nacional de San Martín), Antonio Ramirez-Treviño (Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional), Sebastian Nava-López (Istituto Psicoanalitico per le Ricerche Sociali), Diego Velasco (Istituto Psicoanalitico per le Ricerche Sociali), Óscar Arias-Carrión (Instituto Nacional de Rehabilitación)
Published
2026-04-28
OA status
gold
DOI
10.3389/fpsyt.2026.1824079
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:64b9bf6448a04a40,
  title = {Safety and preliminary efficacy of Aurora: a pilot, non-randomized clinical trial of a culturally adapted digital cognitive behavioral therapy intervention for anxiety and depression in Mexico},
  author = {Edith Zárate and Augusto César Velasco-Téllez and Lucia Araceli Sanchez-Reyes and Angel Mario Coll-Muñoz and Miguel Á. Ramírez-Ramírez and Alejandro López Tello and Christian Gabriel Toledo-Lozano and Ana Moreno-Coutiño and María del Pilar Callejas-Gómez and Raúl Durón-Figueroa and Lorena Alejandra Flores-Plata and Antonio Ramirez-Treviño and Sebastian Nava-López and Diego Velasco and Óscar Arias-Carrión},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.3389/fpsyt.2026.1824079},
  url = {https://doi.org/10.3389/fpsyt.2026.1824079}
}

RIS

TY  - JOUR
TI  - Safety and preliminary efficacy of Aurora: a pilot, non-randomized clinical trial of a culturally adapted digital cognitive behavioral therapy intervention for anxiety and depression in Mexico
AU  - Zárate, Edith
AU  - Velasco-Téllez, Augusto César
AU  - Sanchez-Reyes, Lucia Araceli
AU  - Coll-Muñoz, Angel Mario
AU  - Ramírez-Ramírez, Miguel Á.
AU  - Tello, Alejandro López
AU  - Toledo-Lozano, Christian Gabriel
AU  - Moreno-Coutiño, Ana
AU  - Callejas-Gómez, María del Pilar
AU  - Durón-Figueroa, Raúl
AU  - Flores-Plata, Lorena Alejandra
AU  - Ramirez-Treviño, Antonio
AU  - Nava-López, Sebastian
AU  - Velasco, Diego
AU  - Arias-Carrión, Óscar
PY  - 2026
PB  - PubMed Central
DO  - 10.3389/fpsyt.2026.1824079
UR  - https://doi.org/10.3389/fpsyt.2026.1824079
ER  -

APA

Zárate, E., Velasco-Téllez, A. C., Sanchez-Reyes, L. A., Coll-Muñoz, A. M., Ramírez-Ramírez, M. Á., Tello, A. L., Toledo-Lozano, C. G., Moreno-Coutiño, A., Callejas-Gómez, M. D. P., Durón-Figueroa, R., Flores-Plata, L. A., Ramirez-Treviño, A., Nava-López, S., Velasco, D., & Arias-Carrión, Ó. (2026). Safety and preliminary efficacy of Aurora: a pilot, non-randomized clinical trial of a culturally adapted digital cognitive behavioral therapy intervention for anxiety and depression in Mexico. PubMed Central. https://doi.org/10.3389/fpsyt.2026.1824079

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