The Hidden Burden of COMISA: Clinical Implications and Treatment Challenges

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This narrative review examines comorbid insomnia and sleep apnea (COMISA), detailing its epidemiology, pathophysiology, and diagnostic challenges for clinicians. It highlights the condition's association with severe cardiovascular and mental health risks, noting that standard single-modality treatments often yield limited results. The resource discusses treatment strategies, including combined cognitive behavioral therapy for insomnia with continuous positive airway pressure, as well as emerging pharmacotherapies.

ID
8f86ddd908244bda
Source org
PubMed Central
Author
Cristian Popovici (Nicolae Testemițanu State University of Medicine and Pharmacy), Paschalis Steiropoulos (Democritus University of Thrace), Ștefan Mihăicuță (Precision for Medicine (United States)), Silvia Dumitru (Neurological Institute of Athens), Sofia Dragila (Precision for Medicine (United States)), András Bikov (Manchester Academic Health Science Centre), Alexandru Corlăteanu (Nicolae Testemițanu State University of Medicine and Pharmacy)
Published
2025-11-12
OA status
gold
DOI
10.1007/s41030-025-00331-0
PMID
Not recorded
PMCID
Not recorded
Citations
7

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BibTeX

@article{allodium:8f86ddd908244bda,
  title = {The Hidden Burden of COMISA: Clinical Implications and Treatment Challenges},
  author = {Cristian Popovici and Paschalis Steiropoulos and Ștefan Mihăicuță and Silvia Dumitru and Sofia Dragila and András Bikov and Alexandru Corlăteanu},
  year = {2025},
  journal = {PubMed Central},
  doi = {10.1007/s41030-025-00331-0},
  url = {https://doi.org/10.1007/s41030-025-00331-0}
}

RIS

TY  - JOUR
TI  - The Hidden Burden of COMISA: Clinical Implications and Treatment Challenges
AU  - Popovici, Cristian
AU  - Steiropoulos, Paschalis
AU  - Mihăicuță, Ștefan
AU  - Dumitru, Silvia
AU  - Dragila, Sofia
AU  - Bikov, András
AU  - Corlăteanu, Alexandru
PY  - 2025
PB  - PubMed Central
DO  - 10.1007/s41030-025-00331-0
UR  - https://doi.org/10.1007/s41030-025-00331-0
ER  -

APA

Popovici, C., Steiropoulos, P., Mihăicuță, Ș., Dumitru, S., Dragila, S., Bikov, A., & Corlăteanu, A. (2025). The Hidden Burden of COMISA: Clinical Implications and Treatment Challenges. PubMed Central. https://doi.org/10.1007/s41030-025-00331-0

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