Optimizing expectations in an internet- and mobile-based intervention for depression: study protocol for a randomized factorial trial

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This study protocol outlines a randomized factorial trial investigating how expectation-focused microinterventions influence the effectiveness of an internet- and mobile-based cognitive behavioral intervention for depression. The research involves 720 adult participants with elevated depressive symptoms who are assigned to various combinations of standard or personalized framing and different types of mid-treatment telephone support. Primary outcomes include depression levels measured by the BDI-II, while secondary measures assess expectations, adherence, anxiety, disability, negative effects, and treatment satisfaction.

ID
b1ddb74afa664996
Source org
PubMed Central
Author
Carmen Schaeuffele (Freie Universität Berlin), Manuel Heinrich (Freie Universität Berlin), Stephanie Haering (Philipps University of Marburg), Christina Kampisiou (Freie Universität Berlin), Lara Bellu (Freie Universität Berlin), Sebastian Burchert (Freie Universität Berlin), Marie Puetz (Freie Universität Berlin), Jessica Wabiszczewicz (Freie Universität Berlin), Marcel Wilhelm (Philipps University of Marburg), Pavle Zagorscak (Freie Universität Berlin), Winfried Rief (Philipps University of Marburg), Christine Knaevelsrud (GFZ Helmholtz Centre for Geosciences)
Published
2026-03-17
OA status
gold
DOI
10.1186/s13063-026-09626-2
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:b1ddb74afa664996,
  title = {Optimizing expectations in an internet- and mobile-based intervention for depression: study protocol for a randomized factorial trial},
  author = {Carmen Schaeuffele and Manuel Heinrich and Stephanie Haering and Christina Kampisiou and Lara Bellu and Sebastian Burchert and Marie Puetz and Jessica Wabiszczewicz and Marcel Wilhelm and Pavle Zagorscak and Winfried Rief and Christine Knaevelsrud},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1186/s13063-026-09626-2},
  url = {https://doi.org/10.1186/s13063-026-09626-2}
}

RIS

TY  - JOUR
TI  - Optimizing expectations in an internet- and mobile-based intervention for depression: study protocol for a randomized factorial trial
AU  - Schaeuffele, Carmen
AU  - Heinrich, Manuel
AU  - Haering, Stephanie
AU  - Kampisiou, Christina
AU  - Bellu, Lara
AU  - Burchert, Sebastian
AU  - Puetz, Marie
AU  - Wabiszczewicz, Jessica
AU  - Wilhelm, Marcel
AU  - Zagorscak, Pavle
AU  - Rief, Winfried
AU  - Knaevelsrud, Christine
PY  - 2026
PB  - PubMed Central
DO  - 10.1186/s13063-026-09626-2
UR  - https://doi.org/10.1186/s13063-026-09626-2
ER  -

APA

Schaeuffele, C., Heinrich, M., Haering, S., Kampisiou, C., Bellu, L., Burchert, S., Puetz, M., Wabiszczewicz, J., Wilhelm, M., Zagorscak, P., Rief, W., & Knaevelsrud, C. (2026). Optimizing expectations in an internet- and mobile-based intervention for depression: study protocol for a randomized factorial trial. PubMed Central. https://doi.org/10.1186/s13063-026-09626-2

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