The physiological foundation of extinction improvement by tDCS over the ventromedial prefrontal cortex (vmPFC) in healthy humans: an fMRI study

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This fMRI study investigates how anodal transcranial direct current stimulation (tDCS) over the ventromedial prefrontal cortex influences fear extinction in healthy humans. The research compares physiological and neural responses between participants receiving real tDCS and those receiving sham stimulation during a three-day fear acquisition and extinction paradigm. Findings indicate that real tDCS enhances extinction recall and promotes early activation of safety networks, suggesting potential utility as an adjunct to cognitive behavioral therapy for anxiety disorders.

ID
d78e36601e604ccb
Source org
PubMed Central
Author
Harleen Chhabra (TU Dortmund University), Y H (TU Dortmund University), Erhan Genç (TU Dortmund University), Michael A. Nitsche (TU Dortmund University), Fatemeh Yavari (TU Dortmund University)
Published
2026-06-26
OA status
gold
DOI
10.1038/s41398-026-04190-4
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:d78e36601e604ccb,
  title = {The physiological foundation of extinction improvement by tDCS over the ventromedial prefrontal cortex (vmPFC) in healthy humans: an fMRI study},
  author = {Harleen Chhabra and Y H and Erhan Genç and Michael A. Nitsche and Fatemeh Yavari},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1038/s41398-026-04190-4},
  url = {https://doi.org/10.1038/s41398-026-04190-4}
}

RIS

TY  - JOUR
TI  - The physiological foundation of extinction improvement by tDCS over the ventromedial prefrontal cortex (vmPFC) in healthy humans: an fMRI study
AU  - Chhabra, Harleen
AU  - H, Y
AU  - Genç, Erhan
AU  - Nitsche, Michael A.
AU  - Yavari, Fatemeh
PY  - 2026
PB  - PubMed Central
DO  - 10.1038/s41398-026-04190-4
UR  - https://doi.org/10.1038/s41398-026-04190-4
ER  -

APA

Chhabra, H., H, Y., Genç, E., Nitsche, M. A., & Yavari, F. (2026). The physiological foundation of extinction improvement by tDCS over the ventromedial prefrontal cortex (vmPFC) in healthy humans: an fMRI study. PubMed Central. https://doi.org/10.1038/s41398-026-04190-4

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