Antidepressant-like effects of extinction learning as an animal model of behavioral therapy

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This study uses a rat model of exposure therapy to investigate the neurobiological mechanisms behind the antidepressant effects observed in humans undergoing behavioral treatment for PTSD. The authors found that fear extinction reduced depressive-like behaviors in chronically stressed rats, an effect mediated by activity-dependent neuroplasticity in the ventral medial prefrontal cortex.

ID
51addafc62734a54
Source org
PubMed Central
Author
Jing Liu (The University of Texas at San Antonio Health Science Center), Sarah E. Bulin (The University of Texas at San Antonio Health Science Center), David A. Morilak (The University of Texas at San Antonio Health Science Center)
Published
2025-12-12
OA status
hybrid
DOI
10.1038/s41380-025-03380-8
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:51addafc62734a54,
  title = {Antidepressant-like effects of extinction learning as an animal model of behavioral therapy},
  author = {Jing Liu and Sarah E. Bulin and David A. Morilak},
  year = {2025},
  journal = {PubMed Central},
  doi = {10.1038/s41380-025-03380-8},
  url = {https://doi.org/10.1038/s41380-025-03380-8}
}

RIS

TY  - JOUR
TI  - Antidepressant-like effects of extinction learning as an animal model of behavioral therapy
AU  - Liu, Jing
AU  - Bulin, Sarah E.
AU  - Morilak, David A.
PY  - 2025
PB  - PubMed Central
DO  - 10.1038/s41380-025-03380-8
UR  - https://doi.org/10.1038/s41380-025-03380-8
ER  -

APA

Liu, J., Bulin, S. E., & Morilak, D. A. (2025). Antidepressant-like effects of extinction learning as an animal model of behavioral therapy. PubMed Central. https://doi.org/10.1038/s41380-025-03380-8

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