Self-help cognitive behavioural therapy for hot flushes and night sweats during androgen deprivation therapy for prostate cancer: the MANCAN2 randomized controlled trial

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This randomized controlled trial evaluates a four-week self-help cognitive behavioral therapy program designed to mitigate hot flushes and night sweats in prostate cancer patients undergoing androgen deprivation therapy. The study compares this intervention, guided by nurse specialists, against treatment as usual across 162 participants. Results indicate that while the CBT group showed short-term improvements in symptom severity, anxiety, depression, and medication compliance at six weeks, these benefits were not sustained at the six-month primary endpoint.

ID
d94d2fd26b494e89
Source org
PubMed Central
Author
Simon J. Crabb (University Hospital Southampton NHS Foundation Trust), Alannah Morgan (Cancer Research UK), Evgenia Stefanopoulou, Louisa Fleure, Gareth Griffiths (Cancer Research UK), Cherish Boxall (Cancer Research UK), Sam Wilding (Cancer Research UK), Theodora Nearchou (Cancer Research UK), Sean Ewings (Cancer Research UK), Jacqueline Nuttall (Cancer Research UK), Zina Eminton (Cancer Research UK), Emma Tilt (Cancer Research UK), Emma whitby (Clatterbridge Cancer Centre NHS Foundation Trust), Bernard Siu (Royal Marsden NHS Foundation Trust), Paul Ridley (Ipswich Hospital), Lynsey Robson (South Tyneside and Sunderland NHS Foundation Trust), Jenny Nobes (Norfolk and Norwich University Hospitals NHS Foundation Trust), Joanne Preece (Velindre Cancer Centre), Roger Bacon (Prostate Cancer UK), Jonathan Martin (Cancer Research UK), Sarah Chamberlain (Cancer Research UK), Deborah Fenlon (Swansea University), Myra S. Hunter (King's College London), Alison Richardson (University Hospital Southampton NHS Foundation Trust)
Published
2026-03-24
OA status
hybrid
DOI
10.1038/s41416-026-03375-4
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:d94d2fd26b494e89,
  title = {Self-help cognitive behavioural therapy for hot flushes and night sweats during androgen deprivation therapy for prostate cancer: the MANCAN2 randomized controlled trial},
  author = {Simon J. Crabb and Alannah Morgan and Evgenia Stefanopoulou and Louisa Fleure and Gareth Griffiths and Cherish Boxall and Sam Wilding and Theodora Nearchou and Sean Ewings and Jacqueline Nuttall and Zina Eminton and Emma Tilt and Emma whitby and Bernard Siu and Paul Ridley and Lynsey Robson and Jenny Nobes and Joanne Preece and Roger Bacon and Jonathan Martin and Sarah Chamberlain and Deborah Fenlon and Myra S. Hunter and Alison Richardson},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1038/s41416-026-03375-4},
  url = {https://doi.org/10.1038/s41416-026-03375-4}
}

RIS

TY  - JOUR
TI  - Self-help cognitive behavioural therapy for hot flushes and night sweats during androgen deprivation therapy for prostate cancer: the MANCAN2 randomized controlled trial
AU  - Crabb, Simon J.
AU  - Morgan, Alannah
AU  - Stefanopoulou, Evgenia
AU  - Fleure, Louisa
AU  - Griffiths, Gareth
AU  - Boxall, Cherish
AU  - Wilding, Sam
AU  - Nearchou, Theodora
AU  - Ewings, Sean
AU  - Nuttall, Jacqueline
AU  - Eminton, Zina
AU  - Tilt, Emma
AU  - whitby, Emma
AU  - Siu, Bernard
AU  - Ridley, Paul
AU  - Robson, Lynsey
AU  - Nobes, Jenny
AU  - Preece, Joanne
AU  - Bacon, Roger
AU  - Martin, Jonathan
AU  - Chamberlain, Sarah
AU  - Fenlon, Deborah
AU  - Hunter, Myra S.
AU  - Richardson, Alison
PY  - 2026
PB  - PubMed Central
DO  - 10.1038/s41416-026-03375-4
UR  - https://doi.org/10.1038/s41416-026-03375-4
ER  -

APA

Crabb, S. J., Morgan, A., Stefanopoulou, E., Fleure, L., Griffiths, G., Boxall, C., Wilding, S., Nearchou, T., Ewings, S., Nuttall, J., Eminton, Z., Tilt, E., whitby, E., Siu, B., Ridley, P., Robson, L., Nobes, J., Preece, J., Bacon, R., Martin, J., Chamberlain, S., Fenlon, D., Hunter, M. S., & Richardson, A. (2026). Self-help cognitive behavioural therapy for hot flushes and night sweats during androgen deprivation therapy for prostate cancer: the MANCAN2 randomized controlled trial. PubMed Central. https://doi.org/10.1038/s41416-026-03375-4

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