Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial

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This exploratory placebo-controlled trial investigates whether psychological flexibility mediates the therapeutic effects of psilocybin-assisted therapy for major depressive disorder. The study involved participants receiving both placebo and psilocybin within a framework incorporating Acceptance and Commitment Therapy principles, with outcomes measured over 16 weeks. Results indicate that improvements in psychological flexibility were significantly associated with reduced depression severity following psilocybin administration.

ID
32144a8fe8c142b7
Source org
OpenAlex
Author
Jordan Sloshower (Yale University), Richard J. Zeifman (Multidisciplinary Association for Psychedelic Studies), Jeffrey Guss (New York University), Robert Krause (Yale University), Hamideh Safi-Aghdam (Yale University), Surbhi Pathania (Yale University), Brian Pittman (Yale University), Deepak Cyril D’Souza (Yale University)
Published
2024-04-17
OA status
gold
DOI
10.1038/s41598-024-58318-x
PMID
Not recorded
PMCID
Not recorded
Citations
56

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BibTeX

@article{allodium:32144a8fe8c142b7,
  title = {Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial},
  author = {Jordan Sloshower and Richard J. Zeifman and Jeffrey Guss and Robert Krause and Hamideh Safi-Aghdam and Surbhi Pathania and Brian Pittman and Deepak Cyril D’Souza},
  year = {2024},
  journal = {OpenAlex},
  doi = {10.1038/s41598-024-58318-x},
  url = {https://doi.org/10.1038/s41598-024-58318-x}
}

RIS

TY  - JOUR
TI  - Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial
AU  - Sloshower, Jordan
AU  - Zeifman, Richard J.
AU  - Guss, Jeffrey
AU  - Krause, Robert
AU  - Safi-Aghdam, Hamideh
AU  - Pathania, Surbhi
AU  - Pittman, Brian
AU  - D’Souza, Deepak Cyril
PY  - 2024
PB  - OpenAlex
DO  - 10.1038/s41598-024-58318-x
UR  - https://doi.org/10.1038/s41598-024-58318-x
ER  -

APA

Sloshower, J., Zeifman, R. J., Guss, J., Krause, R., Safi-Aghdam, H., Pathania, S., Pittman, B., & D’Souza, D. C. (2024). Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial. OpenAlex. https://doi.org/10.1038/s41598-024-58318-x

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