An open-label pilot study of psilocybin-assisted therapy for binge eating disorder

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This open-label pilot study examines the feasibility and safety of a single 25 mg dose of psilocybin combined with Acceptance and Commitment Therapy for five adults with Binge Eating Disorder. The resource reports that the intervention was well-tolerated, with participants showing reductions in binge eating frequency, depression, anxiety, and psychological inflexibility over a 14-week period. It also includes preliminary neuroimaging data regarding brain responses to food cues but notes that the small sample size prevents causal inference.

ID
61fcaba362b04fc4
Source org
PubMed Central
Author
Jesse Dallery (University of Florida), Jennifer L. Miller (University of Florida), Jeff Boissoneault (University of Minnesota), Lauren Harvey (University of Florida), Lindsey Ives (Florida State University-Panama), Alexandra Knerr (Johns Hopkins University), Shelby Blaes (University of Florida Health), Morgan N. Ransom (Freedom House), Melissa S. Munson (University of Florida), James P. Gilligan (Australian Physiotherapy Association), Michael H. Silverman, Peter R. Guzzo (Australian Physiotherapy Association), Beverlee Loeser (Australian Physiotherapy Association)
Published
2026-01-03
OA status
gold
DOI
10.1186/s40337-025-01508-3
PMID
Not recorded
PMCID
Not recorded
Citations
1

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BibTeX

@article{allodium:61fcaba362b04fc4,
  title = {An open-label pilot study of psilocybin-assisted therapy for binge eating disorder},
  author = {Jesse Dallery and Jennifer L. Miller and Jeff Boissoneault and Lauren Harvey and Lindsey Ives and Alexandra Knerr and Shelby Blaes and Morgan N. Ransom and Melissa S. Munson and James P. Gilligan and Michael H. Silverman and Peter R. Guzzo and Beverlee Loeser},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1186/s40337-025-01508-3},
  url = {https://doi.org/10.1186/s40337-025-01508-3}
}

RIS

TY  - JOUR
TI  - An open-label pilot study of psilocybin-assisted therapy for binge eating disorder
AU  - Dallery, Jesse
AU  - Miller, Jennifer L.
AU  - Boissoneault, Jeff
AU  - Harvey, Lauren
AU  - Ives, Lindsey
AU  - Knerr, Alexandra
AU  - Blaes, Shelby
AU  - Ransom, Morgan N.
AU  - Munson, Melissa S.
AU  - Gilligan, James P.
AU  - Silverman, Michael H.
AU  - Guzzo, Peter R.
AU  - Loeser, Beverlee
PY  - 2026
PB  - PubMed Central
DO  - 10.1186/s40337-025-01508-3
UR  - https://doi.org/10.1186/s40337-025-01508-3
ER  -

APA

Dallery, J., Miller, J. L., Boissoneault, J., Harvey, L., Ives, L., Knerr, A., Blaes, S., Ransom, M. N., Munson, M. S., Gilligan, J. P., Silverman, M. H., Guzzo, P. R., & Loeser, B. (2026). An open-label pilot study of psilocybin-assisted therapy for binge eating disorder. PubMed Central. https://doi.org/10.1186/s40337-025-01508-3

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