The combination of exercise and psychedelics for the treatment of major depressive disorder

actpapercliniciantier 3link ok

Open source

Overview

AI-generated summary, not a substitute for reading the source.

This commentary explores the potential synergistic effects of combining exercise and psychedelics for treating major depressive disorder, noting that over 50% of patients do not respond to primary treatments. It outlines complementary biological mechanisms, such as distinct impacts on BDNF signaling, neuroplasticity, and connectivity between the hippocampus and default mode network. The authors also discuss psychological benefits, including how psychedelics may facilitate physical activity habits and how exercise may support emotional resilience during psychedelic experiences.

ID
d9b3857b39a44a7a
Source org
PubMed Central
Author
Nicholas Fabiano (University of Ottawa), Brendon Stubbs (King's College London), David W. Lawrence (Mount Sinai Hospital), Joshua D. Rosenblat (Centre for Addiction and Mental Health), Pedro J. Teixeira (University of Lisbon), Stanley Wong (University of Toronto), Carl Zhou (University of Ottawa), Robin Carhart-Harris (University of California, San Francisco)
Published
2026-03-07
OA status
gold
DOI
10.1007/s44192-026-00408-5
PMID
Not recorded
PMCID
Not recorded
Citations
0

Tags

Verification

Automated checks only, not clinical endorsement or advice.

Cite this entry

BibTeX

@article{allodium:d9b3857b39a44a7a,
  title = {The combination of exercise and psychedelics for the treatment of major depressive disorder},
  author = {Nicholas Fabiano and Brendon Stubbs and David W. Lawrence and Joshua D. Rosenblat and Pedro J. Teixeira and Stanley Wong and Carl Zhou and Robin Carhart-Harris},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1007/s44192-026-00408-5},
  url = {https://doi.org/10.1007/s44192-026-00408-5}
}

RIS

TY  - JOUR
TI  - The combination of exercise and psychedelics for the treatment of major depressive disorder
AU  - Fabiano, Nicholas
AU  - Stubbs, Brendon
AU  - Lawrence, David W.
AU  - Rosenblat, Joshua D.
AU  - Teixeira, Pedro J.
AU  - Wong, Stanley
AU  - Zhou, Carl
AU  - Carhart-Harris, Robin
PY  - 2026
PB  - PubMed Central
DO  - 10.1007/s44192-026-00408-5
UR  - https://doi.org/10.1007/s44192-026-00408-5
ER  -

APA

Fabiano, N., Stubbs, B., Lawrence, D. W., Rosenblat, J. D., Teixeira, P. J., Wong, S., Zhou, C., & Carhart-Harris, R. (2026). The combination of exercise and psychedelics for the treatment of major depressive disorder. PubMed Central. https://doi.org/10.1007/s44192-026-00408-5

Related entries

More like this