Fields · Life Sciences · Biochemistry, Genetics and Molecular Biology · Molecular Biology

Protein Kinase Regulation and GTPase Signaling

This cluster of papers focuses on the molecular mechanisms of Ras signaling pathways, including the role of protein kinases, GTPases, and phospholipase C in cell regulation and cancer therapy. It explores the involvement of calcium signaling, cell migration, and transcriptional regulation in oncogenic mutations.

61,473 works

Papers listed on taxonomy pages are the top few works per node from the OpenAlex snapshot. That list is not exhaustive and is not an endorsement. The topic map and the journal registry remain separate: there is still no authoritative topic-to-venue or topic-to-organization edge. Search is a lexical lookup, not a claim that a venue publishes a topic.

Most cited

  1. The role of protein kinase C in cell surface signal transduction and tumour promotion

    Yasutomi Nishizuka · 1984 · Nature · 7,526 citations

  2. Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

    Sandeep Robert Datta, Henryk Dudek, Xu Tao, Shane C. Masters · 1997 · Cell · 5,729 citations

  3. Studies and Perspectives of Protein Kinase C

    Yasutomi Nishizuka · 1986 · Science · 5,141 citations

  4. Rho GTPases in cell biology

    Sandrine Etienne‐Manneville, Alan Hall · 2002 · Nature · 4,815 citations

  5. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

    C. J. Marshall · 1995 · Cell · 4,616 citations

  6. Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

    Yasutomi Nishizuka · 1992 · Science · 4,495 citations

Most recent

  1. Cancer drug resistance: Links between carbonyl reducing enzymes and kinase inhibitors

    Vladimı́r Wsól, Lucie Čermáková, Eva Novotná · 2026 · DOAJ (DOAJ: Directory of Open Access Journals) · 0 citations

  2. In silico analysis of SH3BP2 genomic alterations and expression profiles in CRC

    Muralidharan Jothimani, Karthikeyan Muthusamy · 2026 · Personalized Medicine · 0 citations

  3. Xanthomicrol shifts the ERα/ERβ balance and promotes a less aggressive phenotype in SKOV‑3 ovarian cancer cells

    Isis Santos, Gabriel Gutiérrez‐Ospina, María Adelina Jiménez-Arellanes, Norma Oviedo · 2026 · Natural Product Research · 0 citations

  4. Changes in the transcriptome and synthetic lethal dependencies following KRAS mutant expression reveal profound tissue specificity

    Timothy D. Martin, Mei Yuk Choi, Jana S. McBride, Stephen J. Elledge · 2026 · Proceedings of the National Academy of Sciences · 0 citations

  5. Variante p.Gly143Glu no Gene CES1 Associada a Resposta Adversa ao Metilfenidato numa Criança: Relato de Caso

    Catarina M. Nascimento, Iolanda Faustino, Henrique Brito, Sílvia Afonso · 2026 · Acta Médica Portuguesa · 0 citations

  6. Response to Sotorasib in a patient with recurrent KRAS G12C-mutated low-grade serous ovarian cancer: a case report and literature review

    Erin Hickey Zacholski, Wen Jing Liu, Ryan Clayton, Jaclyn Wall · 2026 · Gynecologic Oncology Reports · 0 citations

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