Clinical and Cost-Effectiveness of Blended Cognitive Behavioral Therapy or Psychodynamic Therapy Versus Face-to-Face Psychotherapy for Depression (BLENDED Study): Protocol for a Pragmatic, Multicenter, Assessor-Blinded Randomized Controlled Noninferiority Trial

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This protocol outlines a pragmatic, multicenter randomized controlled trial comparing blended (online and in-person) cognitive behavioral and psychodynamic therapies against face-to-face versions for adults with major depressive disorder. The study assesses clinical effectiveness, cost-effectiveness, and patient/therapist experiences over two years to evaluate the feasibility of implementing blended care in routine mental health services.

ID
905ab201eeee4136
Source org
PubMed Central
Author
Patrick Luyten (University College London), Danielle Speybrouck (KU Leuven), Peter Martin (University College London), Stephan Claes (Universitair Ziekenhuis Leuven), Nick Midgley (University College London), Hester V. Eeren (Erasmus University Rotterdam), Jan J.V. Busschbach (Erasmus University Rotterdam), Eileen Tang (KU Leuven)
Published
2026-01-14
OA status
gold
DOI
10.2196/80511
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:905ab201eeee4136,
  title = {Clinical and Cost-Effectiveness of Blended Cognitive Behavioral Therapy or Psychodynamic Therapy Versus Face-to-Face Psychotherapy for Depression (BLENDED Study): Protocol for a Pragmatic, Multicenter, Assessor-Blinded Randomized Controlled Noninferiority Trial},
  author = {Patrick Luyten and Danielle Speybrouck and Peter Martin and Stephan Claes and Nick Midgley and Hester V. Eeren and Jan J.V. Busschbach and Eileen Tang},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.2196/80511},
  url = {https://doi.org/10.2196/80511}
}

RIS

TY  - JOUR
TI  - Clinical and Cost-Effectiveness of Blended Cognitive Behavioral Therapy or Psychodynamic Therapy Versus Face-to-Face Psychotherapy for Depression (BLENDED Study): Protocol for a Pragmatic, Multicenter, Assessor-Blinded Randomized Controlled Noninferiority Trial
AU  - Luyten, Patrick
AU  - Speybrouck, Danielle
AU  - Martin, Peter
AU  - Claes, Stephan
AU  - Midgley, Nick
AU  - Eeren, Hester V.
AU  - Busschbach, Jan J.V.
AU  - Tang, Eileen
PY  - 2026
PB  - PubMed Central
DO  - 10.2196/80511
UR  - https://doi.org/10.2196/80511
ER  -

APA

Luyten, P., Speybrouck, D., Martin, P., Claes, S., Midgley, N., Eeren, H. V., Busschbach, J. J., & Tang, E. (2026). Clinical and Cost-Effectiveness of Blended Cognitive Behavioral Therapy or Psychodynamic Therapy Versus Face-to-Face Psychotherapy for Depression (BLENDED Study): Protocol for a Pragmatic, Multicenter, Assessor-Blinded Randomized Controlled Noninferiority Trial. PubMed Central. https://doi.org/10.2196/80511

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